Table 5.
Clinical characteristics of CD patients according to NOD2 genotype
| Clinical features | n1 |
NOD2 genotype, n (%) |
P2 OR (95% CI) | ||||
| WT/WT | R702W/WT | G908R/WT | L1007fsinsC/WT | Heter.compound & homozygous | |||
| Age at diagnosis | |||||||
| < 40 yr (A1 + A2) | 80 | 54 (55.67)3 | 13 (13.40) | 3 (3.09) | 4 (4.12) | 6 (6.18) | 0.57 1.56 (0.46-5.27) |
| > 40 yr (A3) | 17 | 13 (13.40) | 3 (3.09) | 0 | 1 (1.03) | 0 | |
| Location | |||||||
| Ileal (L1) | 34 | 21 (21.65) | 8 (8.25) | 1 (1.03) | 2 (2.06) | 2 (2.06) | 0.26 1.67 (0.69-4.06) |
| Colonic (L2) | 23 | 20 (20.62) | 0 | 1 (1.03) | 1 (1.03) | 1 (1.03) | 0.04 0.26 (0.07-0.96) |
| Ileocolonic (L3) | 40 | 26 (26.80) | 8 (8.25) | 1 (1.03) | 2 (2.06) | 3 (3.09) | 0.5 1.38 (0.57-3.29) |
| Behavior | |||||||
| Non-stricturing, non-penetrating (B1) | 37 | 24 (24.74) | 8 (8.25) | 3 (3.09) | 2 (2.06) | 0 | 0.5 1.37 (0.56-3.29) |
| Stricturing (B2) | 41 | 34 (35.05) | 5 (5.15) | 0 | 0 | 2 (2.06) | 0.01 0.29 (0.11-0.78) |
| Penetrating (B3) | 19 | 9 (9.28) | 3 (3.09) | 0 | 3 (3.09) | 4 (4.12) | 0.02 3.22 (1.14-9.06) |
CD: Crohn's disease; WT: Wildtype. 1Number of CD patients in each subgroup; 2P-values, odds ratios and confidence intervals refer to the comparison of presence versus absence of the at least one mutant NOD2 allele;
3
Results are expressed as number of CD patients (% of CD patients).