Table 3.
Antioxidant/antioxidant enzymes and TBARS levels in swim stress induced ulcer model (n = 6) mean ± SD
| Parameters | Protein (mg/g) | SOD (U/mg) | Catalase (U/mg) | Glutathione Peroxidase (ηmoles/g) | GSH (nmoles/mg) | TBARS ηmoles |
| Stomach | ||||||
| Healthy | 2.23c ± 0.21 | 9.86a ± 1.1 | 829.2c ± 41.6 | 0.21a ± 0.009 | 224c ± 10.0 | 0.31a ± 0.01 |
| Ulcerated | 1.95a ± 0.13 | 19.10c ± 1.8 | 462.4a ± 30.2 | 0.49d ± 0.01 | 121a ± 18.9 | 1.12c ± 0.20 |
| SRPP 100 mg/kg | 1.90a ± 0.09 | 16.32b,c ± 2.1 | 488.1a,b ± 32.8 | 0.34b ± 0.02 | 174b ± 22.1 | 0.94c ± 0.10 |
| SRPP 200 mg/kg | 2.10b ± 0.19 | 13.06b ± 2.6 | 679.6b ± 9.9 | 0.22a ± 0.01 | 208c ± 16.5 | 0.55a,b ± 0.00 |
| Ranitidine | 2.16b ± 0.22 | 15.22b ± 1.2 | 505.5a,b ± 35.5 | 0.39c ± 0.01 | 136a ± 12.1 | 0.92b ± 0.10 |
| Serum | ||||||
| Healthy | 6.62a ± 0.51 | 112.3a ± 28 | 44.20c ± 4.9 | 0.221a ± 0.004 | 23.6c ± 3.0 | 0.165a ± 0.01 |
| Ulcerated | 6.84a ± 0.53 | 264.6d ± 32 | 22.90a ± 3.1 | 0.286c ± 0.02 | 11.1a ± 1.8 | 0.326d ± 0.02 |
| SRPP 100 mg/kg | 6.35a ± 0.59 | 201.1c ± 36 | 28.63b ± 2.3 | 0.298d ± 0.03 | 16.5b ± 2.1 | 0.261c ± 0.03 |
| SRPP 200 mg/kg | 6.95a ± 0.48 | 168.2b ± 21 | 40.12c ± 3.8 | 0.268b ± 0.03 | 19.8b,c ±12.9 | 0.162a ± 0.01 |
| Ranitidine | 6.35a ± 0.63 | 196.3b,c ±23 | 30.82b ± 2.9 | 0.226a ± 0.02 | 12.8a ± 2.6 | 0.186b ± 0.01 |
| Liver | ||||||
| Healthy | 24.2c ± 0.31 | 261.5b ± 41 | 28.42d ± 3.1 | 0.32a ± 0.02 | 414c ± 51 | 0.98a ± 0.13 |
| Ulcerated | 21.9a ± 0.23 | 142.4a ± 18 | 22.18b,c ± 2.6 | 0.58c ± 0.05 | 221a ± 26 | 2.41d ± 0.23 |
| SRPP 100 mg/kg | 23.1b ± 0.28 | 164.2a ± 13 | 19.63b,c ± 2.4 | 0.36a,b ± 0.03 | 315b ± 36 | 1.84c ± 0.16 |
| SRPP 200 mg/kg | 23.9b ± 0.28 | 361.5d ± 39 | 15.54a ± 2.1 | 0.28a ± 0.02 | 214a ± 24 | 1.26b ± 0.11 |
| Ranitidine | 23.6b ± 0.26 | 314.4c,d ± 36 | 17.34a ± 1.9 | 0.32a ± 0.02 | 254a ± 28 | 1.41b ± 0.12 |
SOD: Superoxide dismutase; GSH: Glutathione; TBARS: Thiobarbituric acid reactive substances. Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups.