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. Author manuscript; available in PMC: 2015 Sep 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2014 Jun 3;279(3):266–274. doi: 10.1016/j.taap.2014.05.010

Figure 1. APAP induces cell death in primary human hepatocytes (PHH).

Figure 1

Cells were treated with 5mM or 10mM APAP over a period of 48 hours. (A) Time course of toxicity over 48 hours, as indicated by percentage of alanine aminotransferase (ALT) activity found in the culture medium, (B) Dose-response of APAP toxicity at 24 hours after treatment. (C) Necrotic cell death as indicated by nuclear PI staining after 24h after 10mM APAP exposure. The nucleus was stained with DAPI. Data in A and B represent mean ± SE of 20 independent cell isolations. *P < 0.05 (compared with time 0 or control).