Fig. 3.

Serum VNA and total IgG in brains and sera of immune-competent mice treated with VNA and/or MCP-1. ICR mice (groups of 3) at the age of 4–6 weeks were treated with RABV-antibody positive serum (Ab) with or without recombinant murine MCP-1. Mice were euthanized 24 h after the treatment and both sera and brains were harvested. VNA in brains (A), serum VNA (B), total IgG in brains (C) and serum total IgG (D) were determined. Data are presented as mean values ± SEM. Asterisks indicate significant differences (^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001) between the indicated experimental groups.