Table 2.
Concentration of sICAM-1 in the serum of women with breast cancer in relation to age, clinical stage of disease, lymph node status, tumour size, and histological malignancy grade
| Patient characteristics | mean sICAM-1 concentration [ng/ml] | sICAM-1 median sICAM-1 concentration [ng/ml] | sICAM-1 concentration range [ng/ml] |
|---|---|---|---|
| Control group n = 40 | 591.8 ±170.5 | 611.9 | 305.8–998.4 |
| Breast cancer patients n = 103 | 1674.9* ±765.8 | 1602.1* | 595.9–3492.1 |
| Age Pre-menopausal Post-menopausal |
1610.9* ±779.6 1702.0* ±763.7 |
1554.5* 1602.2* |
632.0–3450.0 595.9–3492.1 |
| Stage of clinical disease advancement according to the TNM | |||
|
I (n = 47) II (n = 38) III (n = 18) |
1133.8* ±457.4 1904.2*& ±481 2603.7*&# ±780 |
1030.0* 1884.7*& 2758.2*&# |
595.9–2417.0 939.0–3147.7 1054.4–3492.1 |
| Axillary lymph nodes status pN0 (n = 51) pN1 (n = 52) |
1237.7* ±558.0 2103.8*▼ ±714 |
1129.4* 2046.5*▼ |
595.9–2758.2 710.3–3492.1 |
| Tumour size pT < 20 mm (n = 54) pT ≥ 20 < 50 mm (n = 40) pT ≥ 50 mm (n = 9) |
274.5* ±241.2 712.4*◆ ±286.1 1132.4*◆■±3404 |
439.9* 704.6*◆ 1207.5*◆■ |
245.0–1420.3 254.2–1516.3 383.4–1516.3 |
| Histological grade of malignancy G1 (n = 11) G2 (n = 50) G3 (n = 42) |
1055.4* ±338.2 1506.1*△ ±682.2 2038.2*△❑ ±775 |
997.2* 1417.0*△ 2042.0*△❑ |
699.1–1826.3 632.0–3450.0 595.9–3492.1 |
n – number of tested individuals
Statistically significant difference for sICAM-1 in comparison to the control group p < 0.05
Statistically significant difference for sICAM-1 in comparison to the women in stage I of clinical disease advancement p < 0.05
Statistically significant difference for sICAM-1 in comparison to the women in stage II of clinical disease advancement p < 0.05
Statistically significant difference for sICAM-1 in comparison to the group of women without metastases to the axillary lymph nodes p < 0.05
Statistically significant difference for sICAM-1 in comparison to the group of women with tumours measuring < 20 mm, p < 0.05
Statistically significant difference for sICAM-1 in comparison to women with tumours measuring ≥ 20 < 50 mm, p < 0.05
Statistically significant difference for sICAM-1 in comparison to women with a G1 histological grade of malignancy, p < 0.05
Statistically significant difference for sICAM-1 in comparison to women with a G2 histological grade of malignancy G2, p < 0.05