Figure 5. Mechanisms of enhanced U46619-mediated contraction in relaxin deficient mice.

Concentration-response curves and sensitivity (pEC₅₀) to the thromboxane mimetic U46619 in endothelium-intact mesenteric arteries from 5 month old Rln^+/+ (▪) and Rln ^−/− (□) mice. Parameters were assessed in the absence of inhibitors (A), and presence of indomethacin (B), L-NAME (C) or TRAM-34 and apamin (D). Values are mean ± SEM. * significantly (P = 0.004) greater than Rln^+/+ mice, n = 5–7.