Table 1. Scenarios for type I error and power simulations.
| Scenario | Setting |
| Type I error | |
| Scen1 | 10 kb1, 500 A2, Caucasian3 |
| Scen2 | 10 kb, 1000 A, Caucasian |
| Scen3 | 10 kb, 1000 AUU, Caucasian |
| Scen4 | 10 kb, 1000 AA, Caucasian |
| Scen5 | 25 kb, 500 A, Caucasian |
| Scen6 | 25 kb, 1000 A, Caucasian |
| Scen7 | 25 kb, 1000 AUU, Caucasian |
| Scen8 | 25 kb, 1000 AA, Caucasian |
| Scen9 | 10 kb, 700 Caucasian trios and 300 African American trios |
| Scen10 | 25 kb, 700 Caucasian trios and 300 African American trios |
| Power | |
| Scen11 | 10 kb, 1000 A, 30% of rare variants are risk variants |
| Scen12 | Same as Scen11. But 30% of the causal variants are changed to protective variants. |
| Scen13 | 10 kb, 1000 A, 30% of common variants are risk variants |
| Scen14 | 10 kb, 1000 A, 10% of common and 10% of rare variants are risk variants |
| Scen15 | 10 kb, 1000 A, 30% of common and 30% of rare variants are risk variants |
| Scen16 | Same as Scen15. But 30% of the causal variants are changed to protective variants |
| Scen17 | 25 kb, 1000 A, 30% of rare variants are risk variants |
| Scen18 | Same as Scen17. But 30% of the causal variants are changed to protective variants. |
| Scen19 | 25 kb, 1000 A, 30% of common variants are risk variants |
| Scen20 | 25 kb, 1000 A, 10% of common and 10% of rare variants are risk variants |
| Scen21 | 25 kb, 1000 A, 30% of common and 30% of rare variants are risk variants |
| Scen22 | Same as Scen21. But 30% of the causal variants are changed to protective variants |
1
Size of the sequence region.
2
A: two parents and one affected sib; AUU: two parents, one affected and two unaffected sibs, AA: two parents and two affected sibs.
3
Simulated population.