Table 2.
Absolute QST values at joint test-site in children with JIA according to joint inflammation status a
| Upper extremity | Lower extremity | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| QST parameter | Active joint (n = 11) | Inactive joint (n = 20) | p-value b | Active joint (n = 12) | Inactive joint (n = 17) | p-value b | ||||
| Innocuous stimulus | ||||||||||
| MDT (g) | 0.05 | (0.04-0.16) | 0.08 | (0.04-0.40) | 0.11 | 0.28 | (0.07-0.43) | 0.40 | (0.18-0.53) | 0.26 |
| VDT (μm/sec) | 0.69 | (0.54-0.84) | 0.64 | (0.57-0.81) | 0.87 | 2.01 | (1.74-3.61) | 4.25 | (2.14-5.35) | 0.21 |
| CDT (°C) | 30.1 | (28.2-30.7) | 30.4 | (29.0-30.9) | 0.83 | 28.5 | (26.2-29.1) | 27.8 | (24.5-29.4) | 0.78 |
| WDT (°C) | 34.7 | (34.3-38.5) | 34.5 | (33.9-35.9) | 0.69 | 37.0 | (36.1-39.2) | 36.9 | (35.7-38.5) | 0.87 |
| Noxious stimulus | ||||||||||
| MPT (g) | 0.40 | (0.06-1.70) | 0.50 | (0.40-3.50) | 0.17 | 0.60 | (0.34-1.00) | 1.00 | (0.40-1.60) | 0.40 |
| PPT (N) | 7.47 | (5.37-15.0) | 10.4 | (6.50-16.3) | 0.27 | 12.6 | (10.3-21.2) | 14.9 | (7.78-21.6) | 0.85 |
| CPT (°C) | 29.4 | (21.6-30.3) | 25.6 | (20.0-28.6) | 0.06 | 24.0 | (16.9-26.9) | 24.6 | (20.4-26.0) | 0.87 |
| HPT (°C) | 36.7 | (35.9-42.9) | 38.2 | (36.3-40.8) | 0.62 | 43.9 | (40.7-45.0) | 41.3 | (39.1-43.2) | 0.19 |
CDT- Cold Detection Threshold, CPT, Cold Pain Threshold; HPT, Heat Pain Threshold; IQR- Inter-Quartile Range; MDT- Mechanical Detection Threshold; MPT- Mechanical Pain Threshold; PPT, Pressure Detection Threshold; VDT- Vibration Detection Threshold; WDT- Warm Detection Threshold.
a.All values given as median (IQR) unless otherwise stated. Eight children with JIA were taking daily NSAIDs at the time of study. Two had active arthritis and were evaluated for QST at the finger or knee; 6 were in clinical remission and were evaluated at the finger (n = 3), knee (n = 1) or ankle (n = 1).b. p-values indicate differences in sensory threshold between Active and Inactive joints using Mann–Whitney U-test.