Table 3.
Absolute QST values at control site (thenar eminence) in children with JIA according to joint inflammation status a
| Upper extremity | Lower extremity | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| QST parameter | Active joint (n = 11) | Inactive joint (n = 20) | Active joint (n = 12) | Inactive joint (n = 17) | p-value b | ||||
| Innocuous stimulus | |||||||||
| MDT (g) | 0.04 | (0.03-0.08) | 0.04 | (0.02-0.05) | 0.04 | (0.02-0.05) | 0.05 | (0.04-0.09) | 0.08 |
| VDT (μm/sec) | 0.58 | (0.42-1.20) | 0.69 | (0.59-1.03) | 0.64 | (0.50-0.81) | 0.80 | (0.63-0.91) | 0.35 |
| CDT (°C) | 30.4 | (29.5-30.8) | 30.2 | (29.7-30.7) | 29.9 | (29.2-30.5) | 30.2 | (27.5-30.6) | 0.60 |
| WDT (°C) | 34.8 | (33.8-36.0) | 34.6 | (34.2-35.2) | 34.8 | (34.2-36.5) | 34.9 | (33.7-35.5) | 0.95 |
| Noxious stimulus | |||||||||
| MPT (g) | 0.8 | (0.4-1.4) | 1.0 | (0.4-2.5) | 1.2 | (0.8-3.7) | 1.3 | (0.6-4.5) | 0.46 |
| PPT (N) | 6.1 | (4.5-15.0) | 10.7 | (8.4-16.3) | 11.3 | (5.8-16.9) | 9.7 | (7.4-15.2) | 0.58 |
| CPT (°C) | 29.1 | (25.0-30.6) | 25.7 | (14.3-29.0) | 21.1 | (15.5-25.4) | 26.6 | (22.0-28.9) | 0.03 c |
| HPT (°C) | 37.2 | (35.7-40.3) | 37.8 | (35.4-43.0) | 41.1 | (38.6-45.5) | 37.5 | (35.9-43.2) | 0.17 |
CDT- Cold Detection Threshold, CPT, Cold Pain Threshold; HPT, Heat Pain Threshold; IQR- Inter-Quartile Range; MDT- Mechanical Detection Threshold; MPT- Mechanical Pain Threshold; PPT, Pressure Detection Threshold; VDT- Vibration Detection Threshold; WDT- Warm Detection Threshold.
a.All values given as median (IQR) unless otherwise stated. Eight children with JIA were taking daily NSAIDs at the time of study. b. p-values indicate differences in sensory threshold between all four groups using Kruskal-Wallis testing. Boldface highlights significant differences. c.Significant differences for CPT found between JIA patients with active arthritis in the upper extremity vs lower extremity after Dunn’s correction for multiple comparisons; no other comparisons were different.