Figure 5.

Correlation between Child-Pugh score and the signal intensity of functional genes. Seven genes correlated negatively with the severity of liver disease, as estimated by the Child-Pugh score, including genes for genes for carbohydrate metabolism (transaldolase) (Figure 5 A), glycan metabolism (phospho-N-acetylmuramoyl-pentapeptide transferase gene) (Figure 5 B), amino acids synthesis (aspartate-ammonia ligase, serine-tRNA ligase and glutamate decarboxylase A and B PLP-dependent gene) (Figure 5 C, D, and E), and nucleotide metabolism (IMP dehydrogenase gene and adenylosuccinate synthetase gene) (Figure 5 F, G). The gene name is on the top of each figure, with the functional category name in brackets. The Spearman Rank correlation (r) and probability (p) with Bonferroni correction was used to evaluate statistical importance.