Table 2.
χ2 tests for identification of prognostic factors for metastasis
| Candidate | Metastasis positive (%) | Metastasis free (%) | P | |
|---|---|---|---|---|
| Sex | Male | 21 (42.0) | 29 (58.0) | 0.31 |
| Female | 13 (31.7) | 28 (68.3) | ||
| Age | ≤ 14 years | 12 (33.3) | 24 (66.7) | 0.52 |
| > 15 years | 22 (40.0) | 33 (60.0) | ||
| Tumor site | Distal femur/Proximal tibia/Proximal humerus (Not exceeding the isthmus) | 12 (21.1) | 45 (78.9) | <0.001 |
| Others | 22 (67.4) | 12 (35.3) | ||
| Laterality | Left | 13 (32.5) | 27 (67.5) | 0.40 |
| Right | 21 (41.2) | 30 (58.8) | ||
| Tumor size | ≥ 8 cm | 25 (40.3) | 37 (59.7) | 0.39 |
| < 8 cm | 9 (31.0) | 20 (69.0) | ||
| Pathologic fracture at diagnosis | Yes | 3 (60.0) | 2 (40.0) | 0.36* |
| No | 31 (36.0) | 55 (64.0) | ||
| Skip lesion | Yes | 2 (66.7) | 1 (33.3) | 0.55* |
| No | 32 (36.4) | 56 (63.6) | ||
| Intracapsular extension | Yes | 13 (65.0) | 7 (35.0) | 0.004 |
| No | 21 (29.6) | 50 (70.4) | ||
| ALP at diagnosis | Elevated | 26 (46.4) | 30 (53.6) | 0.02 |
| Normal | 8 (22.9) | 27 (77.1) | ||
| LDH at diagnosis | Elevated | 5 (55.6) | 4 (44.4) | 0.12* |
| Normal | 14 (26.4) | 39 (73.6) | ||
| Histologic type | Osteoblastic/chondroblastic/fibroblastic | 19 (29.2) | 46 (70.8) | 0.02 |
| Others (mixed and nonconventional type) | 9 (60.0) | 6 (40.0) | ||
| Limb salvage surgery type | Without Pasteurization | 28 (36.4) | 49 (63.6) | 0.64 |
| With Pasteurization | 6 (42.9) | 8 (57.1) | ||
| Huvos grade | I & II | 15 (57.7) | 11 (42.3) | 0.01 |
| III & IV | 19 (29.2) | 46 (70.8) | ||
| Surgical resection | Complete | 28 (32.9) | 57 (67.1) | 0.002* |
| Incomplete | 6 (100.0) | 0 (0.0) | ||
Abbreviation: ALP alkaline phosphatase, LDH lactate dehydrogenase.
*Calculated using Fisher’s extract test.