Table 2. PTK6 expression, activation, and localization in human breast tumors.
PTK6 expression was examined in 125 cores from 44 patients. If a patient had variable PTK6 staining between cores, the highest value is indicated per patient. Subcellular localization patterns of PTK6 (membrane, cytoplasm and nucleus) are not always mutually exclusive
| Antibodies and intracellular localization | PTK6 Positive | Signal strength | ||||
|---|---|---|---|---|---|---|
| 0 | 1+ | 2+ | 3+ | |||
| Total PTK6 | Cytoplasm | 43 (97.7%) | 1 (2.3%) | 13 (29.5%) | 28 (63.6%) | 2 (4.5%) |
| Nucleus | 20 (45.4%) | 24 (54.5%) | 7 (15.9%) | 12 (27.3%) | 1 (2.3%) | |
| PTK6 P-Y342 | Membrane | 18 (40.9%) | 26 (59.1%) | 12 (27.2%) | 4 (9.1%) | 2 (4.5%) |
| Cytoplasm | 14 (31.8%) | 30 (68.2%) | 11 (25.0%) | 3 (6.8%) | 0 (0%) | |
| Nucleus | 5 (11.4%) | 39 (88.6%) | 4 (9.1%) | 1 (2.3%) | 0 (0%) | |