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. 2014 Jul 7;5(15):6113–6129. doi: 10.18632/oncotarget.2176

Figure 4. Effect of miR-451 expression on in vivo radiosensitivity of docetaxel-resistant LAD cells.

Figure 4

(A) Growth of tumors in the nude mice subcutaneously transplanted with 3.0×106 pcDNA/miR-NC or pcDNA/miR-451-transfected H1299/DTX cells combined with irradiation treatment. Six mice of each group were used for the subcutaneous transplantation. Representative photographs of tumors were provided at 6 weeks after the inoculation. Data were the mean ± standard error. (B1-3), Hematoxylin and eosin (H & E) staining analysis of proliferating cell nuclear antigen (PCNA and Ki67) expression in tumors developed from pcDNA/miR-NC or pcDNA/miR-451-transfected H1299/DTX cells combined with irradition treatment. Bars, 50 μm. (C)TUNEL staining detection of apoptosis in tumors developed from pcDNA/miR-NC or pcDNA/miR-451-transfected H1299/DTX cells combined with irradiation treatment. Bars, 50μm. Results represent the average of three independent experiments (mean ± SD). *P< 0.05 and **P< 0.01.