Table 2. Multivariate disease-free survival analysis of EEC according to MSI and ploidy.
| Whole series1 | Diploid tumors | MSS tumors | Whole series2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (No. of patients = 155) | (No. of patients = 136) | (No. of patients = 125) | (No. of patients = 155) | |||||||||
| (No. of events = 32) | (No. of events = 25) | (No. of events = 20) | (No. of events = 32) | |||||||||
| Characteristic | HR (95%CI) | Wald Χ2 | p-value | HR (95%CI) | Wald Χ2 | p-value | HR (95%CI) | Wald Χ2 | p-value | HR (95%CI) | Wald Χ2 | p-value |
| Age (years) | 1.0 (1.0-1.1) | 4.1 | 0.04 | 1.1 (1.0-1.1) | 4.4 | 0.04 | - | 1.0 (1.0-1.1) | 2.8 | 0.09 | ||
| Stage | 0.00 | 0.02 | 0.00 | 0.00 | ||||||||
| I | 1* | 1* | 1* | 1* | ||||||||
| II | 2.5 (1.0-6.2) | 4.0 | 0.05 | 3.6 (1.3-10.1) | 5.7 | 0.02 | 0.72 | 2.7 (1.1-6.7) | 4.4 | 0.04 | ||
| III | 8.2 (3.5-19.0) | 23.8 | 0.00 | 6.9 (2.1-22.3) | 10.4 | 0.01 | 11.8 (4.2-32.8) | 22.4 | 0.00 | 5.6 (2.3-13.8) | 14.3 | 0.00 |
| Grade | 0.03 | 0.23 | 0.03 | 5.5 | 0.06 | |||||||
| '1 | 1* | 1* | 1* | |||||||||
| '2 | 0.15 | 0.15 | 0.40 | |||||||||
| '3 | 3.3 (1.4-8.2) | 6.9 | 0.01 | 4.7 (1.4-15.2) | 6.5 | 0.01 | 2.9 (1.2-7.2) | 5.4 | 0.02 | |||
| MSI status | NOT APPLICABLE | |||||||||||
| MSS | 1* | 1* | ||||||||||
| MSI | 0,15 | 2.9 (1.2-6.9) | 5.6 | 0.02 | 2.4 (1.0-5.9) | 3.6 | 0.05 | |||||
| Ploidy | NOT APPLICABLE | |||||||||||
| Diploid | 1* | |||||||||||
| Aneuploid | 0,29 | 0,37 | 2.4 (1.0-6.4) | 2.8 | 0.09 | |||||||
1
MS status and ploidy were added separately to the basic model
2
MS status and ploidy were added at the same time to the basic model
*
Reference category
HR (95%CI) = hazard ratio (95% confidence interval)