Table 3. Synopsis of patient data.
Patient characteristics (top), target and effector cell content (center) and specific antibody binding capacity for CD3, CD19, CD20 and CD33 of malignant cells in the peripheral blood as determined with the QIFIKIT (Dako) (bottom).
Patient 1 (green) | Patient 2 (red) | Patient 3 (blue) | Patient 4 (yellow) | Patient 5 (purple) | ||
---|---|---|---|---|---|---|
Gender | Male | Male | Male | Female | Male | |
Age | 19 years | 86 years | 78 years | 67 years | 52 years | |
Diagnosis | Mixed phenotype acute leukemia (MPAL (NOS)) | CD19-positive NHL with leukemic progression | B-CLL | Relapsed B-CLL | B-CLL | |
Blast titer | 93.4% blasts in BM at diagnosis | 58% of lymphocytes in the PB are CD19-positive | 29,000 B-CLL cells/μL | 65% lymphocytes in the PB (9% atypical) | 42% lymphocytes in the PB | |
Case history | newly diagnosed | newly diagnosed | newly diagnosed | 4 years prior: 6x MabThera® plus fludarabine and cyclophosphamide > CR | newly diagnosed | |
% CD19+ in PBMCs | 94.8 | 21 | 89.8 | 68.8 | 73.2 | |
% CD3+ in PBMCs | 0.8 | 56.1 | 6.8 | 16.6 | 8.6 | |
Specific antibody binding capacity (SABC) of tumour cells in the peripheral blood | CD3 | 211 | n.d. | n.d. | n.d. | n.d. |
CD19 | 8,400 ± 2,800 | 14,600 ± 7,700 | 9,600 ± 500 | 6,500 ± 1,700 | 7,600 ± 1,900 | |
CD20 | 0 | 19,400 ± 2,200 | 4,000 ± 100 | 1,800 ± 300 | 3,900 ± 1,200 | |
CD33 | 317 | n.d. | n.d. | n.d. | n.d. |