Table 3. Synopsis of patient data.
Patient 1 (green) | Patient 2 (red) | Patient 3 (blue) | Patient 4 (yellow) | Patient 5 (purple) | ||
---|---|---|---|---|---|---|
Gender | Male | Male | Male | Female | Male | |
Age | 19 years | 86 years | 78 years | 67 years | 52 years | |
Diagnosis | Mixed phenotype acute leukemia (MPAL (NOS)) | CD19-positive NHL with leukemic progression | B-CLL | Relapsed B-CLL | B-CLL | |
Blast titer | 93.4% blasts in BM at diagnosis | 58% of lymphocytes in the PB are CD19-positive | 29,000 B-CLL cells/μL | 65% lymphocytes in the PB (9% atypical) | 42% lymphocytes in the PB | |
Case history | newly diagnosed | newly diagnosed | newly diagnosed | 4 years prior: 6x MabThera® plus fludarabine and cyclophosphamide > CR | newly diagnosed | |
% CD19+ in PBMCs | 94.8 | 21 | 89.8 | 68.8 | 73.2 | |
% CD3+ in PBMCs | 0.8 | 56.1 | 6.8 | 16.6 | 8.6 | |
Specific antibody binding capacity (SABC) of tumour cells in the peripheral blood | CD3 | 211 | n.d. | n.d. | n.d. | n.d. |
CD19 | 8,400 ± 2,800 | 14,600 ± 7,700 | 9,600 ± 500 | 6,500 ± 1,700 | 7,600 ± 1,900 | |
CD20 | 0 | 19,400 ± 2,200 | 4,000 ± 100 | 1,800 ± 300 | 3,900 ± 1,200 | |
CD33 | 317 | n.d. | n.d. | n.d. | n.d. |