. Author manuscript; available in PMC: 2014 Sep 23.

Published in final edited form as: Trends Mol Med. 2013 Aug 13;19(10):625–632. doi: 10.1016/j.molmed.2013.07.006

Table 1. CD69 role in animal models of disease.

Disease	Animal model	Cell Type	Tissue	References
Collagen-induced arthritis	C57BL/6J CD69^−/−	T and B cells	Synovial leukocytes	[17]
Anti-type-II collagen induced arthritis	C57BL/6J CD69^−/−	Neutrophils	Joints	[2, 3]
Ovalbumin-induced allergic airway inflammation	Balb/c CD69^−/−	Th2/Th17 cells	Lugs and airways	[4, 5]
Lung inflammation after Bleomycin	C57BL/6J CD69^−/−	Macrophages, Neutrophils and lymphocytes	Lungs	[6]
Cigarette smoke Induced inflammation	C57BL/6J CD69^−/−	Macrophages and Neutrophils	Lungs	[7]
Contact hypersensitivity to oxazolone	C57BL/6J CD69^−/−	Th1/Th17	Skin	[5]
Experimental autoimmune myocarditis	Balb/c CD69^−/−	Th17 cells	Myocardium.	[18]
Systemic lupus erythematosus	NZB×NZW mice	CD4⁺CD69⁺ T cells	Peripheral lymphoid tissues, kidney, and lung	[67]
Listeria monocytogenes infection	C57BL/6J CD69^−/− and Balb/c CD69^−/−	Th1	Liver and spleen	[66]
Hepatocarcinoma	C57BL/6J and BALB/c mice	New subset of regulatory CD4⁺ T cells	Spleen and mesenteric lymph nodes	[23]
CD4 T cell transfer colitis	C57BL/6J CD69^−/−	Th17 cells	Bowel	[19]