Table 3.

Transcription factors and cytokines required for mouse NKp46⁺ ILC development and survival.

	Id2	NFIL3	GATA-3 (Vav-Cre or chimeras)	GATA-3 (Id2-CreERt2)	GATA-3 (Ncr1-Cre)	PLZF	Eomes	T-bet	RORγt	IL-7R	IL-15
Splenic cNK	↓ ↓ ↓	↓ ↓ ↓	→	n.d.	n.d.	n.d.	↓ ↓ ↓	→ or↓↓	→	↑ ↑	↓ ↓ ↓
Liver VLA2⁺ cNK	n.d.	↓ ↓ ↓	n.d.	n.d.	n.d.	→	↓ ↓ ↓	→	n.d.	→	↓ ↓ ↓
Liver VLA2⁻ ILC1	n.d.	→¹ or ↓↓²	n.d.	n.d.	n.d.	↓ ↓	→	↓ ↓ ↓	n.d.	n.d.	↓ ↓ ↓
Intestinal LP cNK	n.d.	↓ ↓ ↓	n.d.	n.d.	→	n.d.	↓ ↓ ↓	→	→	↑ ↑	↓ ↓ ↓
Intestinal LP ILC1	n.d.	↓ ↓ ↓	n.d.	n.d.	↓ ↓ ↓	n.d.	→	↓ ↓ ↓	→	→	↓ ↓
Intestinal LP ex-RORD[unk]t⁺ ILC3	n.d.	↓ ↓ ↓	n.d.	n.d.	→	n.d.	→	↓ ↓ ↓	↓ ↓ ↓	↓ ↓ ↓	↓ ↓
Intraepithelial ILC1	↓ ↓ ↓	↓ ↓ ↓	↑ ↑	n.d.	n.d.	→	n.d.	↓ ↓ ↓	→	n.d.	↓ ↓
Uterine VLA2⁺ cNK	n.d.	↓ ↓ ↓	n.d.	n.d.	n.d.	n.d.	↓ ↓ ↓	→	n.d.	n.d.	↓ ↓ ↓
Uterine VLA2⁻ ILC1	n.d.	→	n.d.	n.d.	n.d.	n.d.	→	→	n.d.	n.d.	↓ ↓ ↓
Salivary gland NKp46⁺	n.d.	→	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	↓ ↓ ↓
Thymic NKp46⁺	→ (?)	↓ ↓	↓ ↓ ↓	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	↓ ↓ ↓	→
ILC2 (LP, visceral fat, lung)	↓ ↓ ↓	↓ ↓	↓ ↓ ↓	↓ ↓ ↓	n.d.	↓ ↓	n.d.	n.d.	→	↓ ↓ ↓	→
Intestinal LP CCR6⁺ ILC3	↓ ↓ ↓	↓ ↓	↓ ↓ ↓	→	n.d.	→	→	→	↓ ↓ ↓	↓ ↓ ↓	→
Intestinal LP CCR6^−/low ILC3	↓ ↓ ↓	↓ ↓	↓ ↓ ↓	→	n.d.	→		→ (NKp46⁺ subset ↓↓↓)	↓ ↓ ↓

n.d., not determined; ↓↓↓, population strictly requires factor for development; ↓↓, population is reduced; →, no change in population size; ↑↑, population size is increased

Seillet (2014a) and Sojka (2014) have reported virtually normal numbers of liver VLA2⁻ ILC1 in Nfil3^−/− mice

Kamizono (2009) and Crotta (2014) have reported reduced of liver VLA2⁻ ILC1 in Nfil3^−/− mice