Table 4.
Multivariate binary logistic regression analysis of factors associated with bleeding complications
| Characteristics | Bleeding | Multivariate | |||
|---|---|---|---|---|---|
| |
Yes |
No |
P-value |
OR (95% CI) |
|
| Sex |
Male |
11 |
43 |
|
1 |
| Female |
11 |
67 |
0.38 |
2.13 (0.38-11.82) |
|
| Residence |
Urban |
14 |
63 |
|
1 |
| Rural |
8 |
48 |
0.15 |
3.76 (0.60-23.47) |
|
| Age |
15-39 |
11 |
62 |
|
1 |
| 40-64 |
8 |
36 |
0.75 |
0.72 (0.09-5.49) |
|
| 65 and above |
3 |
13 |
0.07 |
0.08 (0.05-1.31) |
|
| Warfarin dose |
2.5 mg |
3 |
22 |
|
1 |
| 5 mg |
14 |
64 |
0.44 |
0.40 (0.04-4.15) |
|
| 7.5 mg |
3 |
19 |
0.77 |
1.63 (0.06-43.75) |
|
| ≥10 mg |
2 |
6 |
0.20 |
0.11 (0.00-3.19) |
|
| Duration of treatment |
<1 month |
2 |
18 |
|
1 |
| 1-3 months |
8 |
49 |
0.83 |
1.39 (0.07-27.99) |
|
| >3 month |
12 |
44 |
0.66 |
1.98 (0.09-42.18) |
|
| Number of drugs |
<3 |
6 |
20 |
|
1 |
| 3-5 |
8 |
27 |
0.99 |
1.03 (0.02-55.25) |
|
| 6-8 |
4 |
36 |
0.16 |
2.7 (0.68-10.71) |
|
| >8 |
4 |
28 |
0.29 |
2.10 (0.52-8.42) |
|
| Number of interactions |
<2 |
7 |
25 |
|
1 |
| 2-4 |
9 |
62 |
0.92 |
0.82 (0.02-41.11) |
|
| ≥5 |
6 |
24 |
0.24 |
0.05 (0.00-7.13) |
|
| Type of interaction |
Moderate |
13 |
54 |
|
1 |
| Major |
9 |
56 |
0.39 |
1.52 (0.60-3.80) |
|
| INR value | <5 |
2 |
95 |
|
1 |
| ≥5 | 20 | 16 | 0.00* | 0.03 (0.00-0.46) | |
*Statistically significant association.