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. Author manuscript; available in PMC: 2015 Jul 11.
Published in final edited form as: Curr Opin Microbiol. 2014 Jul 11;19:83–89. doi: 10.1016/j.mib.2014.06.004

Figure 2.

Figure 2

Dynamics of the changes in the frequency of resistance and equilibrium frequencies of colonized hosts. Standard parameter values, vS −0.1 per day, vST − 0.2 per day, vR − 0.1 per day, β − 0.12 (R0 vS =1.2 * 0.1) as=0, aR = 0.05 (cost of resistance), kR=0.15. (A) Changes in the frequency of resistance as a function of the maximum frequency of patients treated, TMAX with no external input, xs=xr=0. Red TMAX =0.05, Blue TMAX =0.10, Green TMAX =0.20, Purple TMAX =0.30. (B) Decline in the frequency of resistance with reductions in antibiotic use and rates of acquired resistance. Lines from the top, Purple (tmax=0.10, kR =015, μ=0.01), Red (tMAX =0.05, kR=0.15, μ=0.01, Blue (tMAX =0.05, kR=0.15, μ=0.0001) Green (TMAX =0.05, kR=0.05, μ=0.0001). (C) Changes in the frequency of resistance with external input, TMAX =0.30, Red, xs=xr=0, Blue xs=xr=1E-3, Green, xs=xr=1E-4. D) Equilibrium frequencies of infected hosts for different levels of treatment. Green, TMAX =0, Red TMAX =0.10, Blue TMAX =0.2, Orange TMAX =0.3, Purple TMAX =0.4