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Annual rate of opioid-related mortality (per 1 000 000 population) in Ontario, 1991–2010. Deaths abstracted from the Office of the Chief Coroner of Ontario were deemed opioid-related by the coroner if post-mortem toxicological analysis revealed opioid concentrations sufficiently high to cause death, or if a combination of drugs (including at least one opioid at clinically significant levels) contributed to death. Rates presented per 1 000 000 population
