Fig. 1.

Dexmedetomidine plasma concentrations from nine piglets at varying infusion rates following hypoxic-ischaemic brain injury and co-administration with hypothermia. One additional piglet did not incur brain injury and did not undergo hypothermia. The safe sedative concentration in human neonates is 0.4–0.8 μg/ml; the dotted line is at 1 μg/ml. All piglets achieved dexmedetomidine concentrations above 1 μg/ml.