. 2014 Apr 13;58(6):733–742. doi: 10.1111/aas.12318

Table 3.

Dexmedetomidine infusion rates and plasma concentrations for each piglet. The timing of the hypothermia (cooling to 33.5°C; HT), normothermia (NT) and rewarming (RW) phases are shown. The timing of the cardiac arrest and resuscitation are shown for those subjects with these events. The oxygen saturation (O2 sats), heart rate (HR) and mean arterial blood pressure (MABP) for time points corresponding to when dexmedetomidine plasma levels were taken are shown. (BL: baseline)

Piglet	DEX dose μg/kg/h	Time	DEX plasma level (μg/ml)	Temp	Arrests?	O₂ Sats %	HR Beat/min	MABP
Study 1
1-1	0	BL	–	NT		98	136	37
1-2	0	0.5 h	–	NT		98	140	55
1-3	0	1 h	–	NT		97	147	56
1-4	1.5	6 h	–	HT		98	98	54
1-5	1.5	9 h	3.412	HT		98	90	46
1-6	1.5	12 h	4.473	HT		98	98	47
1-7	1.5	24 h	6.916	RW	Fatal arrest	100	94	37
Study 2
2-1	0	BL	–	NT		98	133	45
2-2	1.5	0.5 h	1.047	NT		98	132	51
2-3	1.5	1 h	1.226	NT		97	136	49
2-4	1.5	2 h	1.713	NT		97	135	46
2-5	1.5	6 h	3.191	NT		95	137	52
2-6	1.5	9 h	3.855	NT		98	145	50
2-7	1.5	12 h	5.141	NT		99	147	51
2-8	1.5	24 h	8.052	NT		98	149	49
2-9	1.5	48 h	8.115	NT		97	135	56
Study 3
3-1	0	BL	–	NT		99	154	42
3-2	1.5	0.5 h	–	NT		96	166	53
3-3	1.5	1 h	2.179	NT		99	130	46
3-4	1.5	2 h	2.636	NT		99	131	48
3-5	1.5	6 h	3.809	HT		99	95	47
3-6	1.5	9 h	4.307	HT		98	92	41
3-7	1.5	12 h	6.660	HT		99	88	33
3-8	1.5	24 h	13.511	RW		99	164	43
3-9	1.5	48 h	5.877	NT		99	189	44
Study 4
4-1	0	BL	–	NT		98	154	41
4-2	1.5	0.5 h	1.869	NT		98	141	46
4-3	1.5	1 h	1.685	NT		98	140	45
4-4	1.5	2 h	3.076	NT		98	134	46
4-5	1.5	6 h	4.563	HT		99	93	45
4-6	1.5	9 h	6.656	HT		99	84	46
4-7	1.5	12 h	7.763	HT		100	95	45
4-8	1.5	24 h	9.067	RW		97	131	35
4-9	1.5	48 h	7.470	NT		98	127	49
Study 5
5-1	0	BL	–	NT		99	175	51
5-2	1.5	0.5 h	–	NT		99	187	50
5-3	1.5	2 h	–	NT		94	169	51
5-4	1.5	6 h	0.929	HT		100	111	48
5-5	1.5	9 h	2.449	HT		100	115	50
5-6	1.5	12 h	3.579	HT		100	153	45
5-7	1.5	18 h	7.065	HT		98	117	48
5-8	1.5	24 h	8.954	RW		98	105	33
5-9	1.5	30 h	–	NT		99	143	48
5-10	1.5	40 h	11.886	NT		80	146	34
5-11	1.5	48 h	6.506	NT	Fatal arrest	80	146	34
Study 6
6-1	0	BL	–	NT		94	125	44
6-2	0	0.5 h	–	NT		91	111	37
6-3	0.8	1 h	0.930	NT		94	100	58
6-4	0.8	6 h	1.400	HT		97	135	60
6-5	0.8	12 h	2.201	HT		96	103	50
6-6	0.8	16 h	5.767	HT		98	173	28
6-7	0.8	24 h	27.519	RW	Arrest-resuscitated	98	181	34
6-8	0.8	30 h	1.620	NT		96	178	55
6-9	0.8	36 h	2.131	NT		97	160	78
6-10	0.8	48 h	1.772	NT		97	107	54
Study 7
7-1	0	BL	–	NT		94	155	35
7-2	0.6	0.5 h	–	NT		93	231	54
7-3	0.6	1 h	–	NT		93	220	43
7-4	0.6	2 h	0.622	NT		95	190	44
7-5	0.6	6 h	0.082	HT		98	154	53
7-6	0.6	9 h	0.096	HT		99	145	72
7-7	0.6	12 h	0.221	HT		98	161	64
7-8	0.6	18 h	0.353	HT		98	125	59
7-9	0.6	24 h	1.041	RW	Fatal arrest	99	169	65
Study 8
8-1	0	BL	–	NT		88	235	45
8-2	0.6	0.5 h	–	NT		90	202	43
8-3	0.6	1 h	–	NT		94	189	35
8-4	0.6	2 h	–	NT		95	185	36
8-5	0.6	6 h	–	HT		97	178	51
8-6	0.6	9 h	0.276	HT		98	158	43
8-7	0.6	12 h	1.301	HT		98	151	44
8-8	0.6	24 h	3.190	RW	Fatal arrest		50	15
Study 9
9-1	0	BL	–	NT		100	160	58
9-2	0	0.5 h	–	NT		99	144	61
9-3	10	6 h	8.736	HT		98	181	49
9-4	10	12 h	32.551	HT		99	141	41
9-5	10	26 h	27.614	RW			175	33
9-6	10	30 h	23.353	NT		95	173	35
9-7	10	36 h	29.608	NT	Fatal arrest	98	170	35
Study 10
10-1	0	BL	–	NT		92	160	61
10-2	0	0.5 h	–	NT		98	167	51
10-3	0	2 h	–	NT		100	158	46
10-4	2	6 h	0.614	HT		99	92	38
10-5	6	12 h	2.489	HT		100	104	54
10-6	8	18 h	9.649	HT		99	124	40
10-7	10	24 h	18.369	HT	Arrest-resuscitated	99	126	58
10-8	10	36 h	39.020	NT		95	185	42
10-9	10	48 h	44.115	NT		96	93	56