. 2014 Sep 6;4(6):490–506.

Table 1.

Overview of kinetic modeling work with regard to hypoxia using different hypoxia PET tracers

Tracer	Image Targeting	Methods	Application	Species	Authors
¹⁸F-FMISO	Hypoxia	Voxelwise kinetic modeling	Oncology/Prostate tumor	Rat	Bartlett et al. [23]
¹⁸F-FMISO	Hypoxia	Noninvasive pO₂ measurement	Oncology/Prostate tumor	Rat	Bartlett et al. [23]
¹⁸F-FMISO	-	Kinetic model	Oncology	Rat	Casciari et al. [64]
³H-FMISO	-	Monte Carlo simulations	Oncology	Patient	Casciari et al. [64]
¹⁸F-FMISO	Hypoxia, perfusion	Dynamic PET	Oncology/Brain tumor	Patient	Bruehlmeier et al. [68]
¹⁵O-H₂O		Kinetic models
		Logan graphical analysis
¹⁸F-FMISO	Hypoxia, perfusion	Patlak graphical analysis	Oncology/Spontaneous sarcomas	Dog	Bruehlmeier et al. [69]
¹⁵O-H₂O	Hypoxia, perfusion	Patlak graphical analysis	Oncology/Spontaneous sarcomas	Dog	Bruehlmeier et al. [69]
¹⁸F-FMISO	Hypoxia	Modular simulation	Oncology/Model evaluation	Simulation work	Kelly and Brady et al. [65]
¹⁸F-FMISO	Hypoxia	Probability density function	Oncology/Model evaluation	Simulation work	Kelly and Brady et al. [65]
¹⁸F-FMISO	Hypoxia	Kinetic model	Oncology/Model evaluation	Phantom study	Wang et al. [72]
¹⁸F-FMISO	Hypoxia	Pharmacokinetic analysis	Oncology/Head and neck cancer	Patient	Wang et al. [73]
¹⁸F-FMISO	Hypoxia	Dynamic PET/CT	Oncology/Head and neck cancer	Patient	Wang et al. [73]
¹⁸F-FMISO	Hypoxia, perfusion	Dynamic PET	Oncology/Head and neck cancer	Patient	Thorwarth et al. [70]
¹⁸F-FMISO	Hypoxia, perfusion	Two compartment model	Oncology/Head and neck cancer	Patient	Thorwarth et al. [70]
¹⁸F-FMISO	Hypoxia	Dynamic PET	Oncology/Radiotherapy	Patient	Thorwarth et al. [42]
¹⁸F-FMISO	Hypoxia	Two compartment model	Oncology/Radiotherapy	Patient	Thorwarth et al. [42]
¹⁸F-FMISO	Hypoxia	DCE-MRI	Oncology/Prostate tumor	Rat	Cho et al. [71]
		Dynamic PET
		Autoradiography
¹⁸F-FMISO	Hypoxia	Dynamic PET	Oncology/Non-immunogenic carcinoma	Mouse	Bejot et al. [67]
¹⁸F-3-NTR	Hypoxia	Compartment modeling	Oncology/Non-immunogenic carcinoma	Mouse	Bejot et al. [67]
¹⁸F-FMISO	Hypoxia	Dynamic PET	Scan protocol validation	Mouse	Whisenant et al. [66]
¹⁸F-FDG		Graphical analysis
¹⁸F-FDG		Graphical analysis
¹⁸F-FMISO	Stroke	Dynamic PET	Stroke	Rat	Takasawa et al. [74]
¹⁸F-FMISO	Hypoxia	Dynamic PET	Stroke	Rat	Hong et al. [75]
¹⁸F-FMISO	Hypoxia	Voxelwise Kinetic analysis based on basis function method	Stroke	Rat	Hong et al. [75]
¹⁸F-FETMIN	Hypoxia	Dynamic PET	Oncology/Head and neck cancer	Patient	Lehtio et al. [80]
		Tumor to plasma ratio
		Tumor to plasma ratio
¹⁸F-FETMIN	Hypoxia	Dynamic PET	Oncology/Head and neck cancer	Patient	Lehtio et al. [81]
¹⁸F-FETMIN	Hypoxia	Compartment analysis	Oncology/Head and neck cancer	Patient	Lehtio et al. [81]
¹⁸F-FAZA	Hypoxia	Dynamic PET	Oncology/Squamous cell carcinoma	Mouse	Busk et al. [87]
		Immunohistochemical staining
		Immunohistochemical staining
¹⁸F-FAZA	Hypoxia, perfusion	Dynamic PET	Oncology/Head and neck cancer	Patient	Shi et al. [88]
¹⁵O-H₂O	Hypoxia, perfusion	Kinetic model	Oncology/Head and neck cancer	Patient	Shi et al. [88]
¹⁸F-FAZA	Hypoxia	Dynamic PET/CT	Oncology/No-small cell lung cancer	Patient	Verwer et al. [89]
⁶⁰Cu-ATSM	Hypoxia	Compartment analysis	Myocardial ischemia	Dog	Lewis et al. [97]
⁶⁴Cu-ATSM
⁶⁴Cu-ATSM
⁶⁴Cu-ATSM	Hypoxia	Non-steady-state kinetic simulations	Oncology/EMT6 murine carcinoma	Mouse	Holland et al. [100]
⁶¹Cu-ATSM	Hypoxia	Electrochemical model	Oncology/Head and neck cancer	Patient	Bowen et al. [101]
¹⁸F-FMISO		Transformation function
		pO₂ microelectrode
⁶⁴Cu-ATSM	Hypoxia	Kinetic modeling	Oncology/Radiotherapy	Simulation work	Dalah et al. [102]
⁶⁴Cu-ATSM	Hypoxia	Dynamic PET	Oncology/Head and neck squamous cell carcinoma	Rat	McCall et al. [103]
		Autoradiography
		Immunohistochemical staining
⁶²Cu-PTSM	Hypoxia, perfusion	Dynamic PET	Multiple tracer protocol	Simulation work	Rust et al. [104]
⁶²Cu-ATSM	Hypoxia, perfusion	⁶²Cu-ATSM	Multiple tracer protocol	Simulation work	Rust et al. [104]
⁶²Cu-PTSM	Hypoxia, perfusion	Dynamic PET	Multiple tracer protocol	Dog	Black et al. [105]
⁶²Cu-ATSM	Hypoxia, perfusion	Compartment analysis	Signal separation and recovery	Dog	Black et al. [105]
¹⁸F-FDG	Hypoxia, perfusion and glycolysis	Dynamic PET	Multiple tracer protocol	Dog	Black et al. [106]
⁶²Cu-PTSM		Compartment analysis	Signal separation and recovery
⁶²Cu-ATSM