Table 2.

Biodistribution of ¹¹¹In-DOTA-GSG-J18 in SKOV-3 tumor-bearingnude mice

Pharmacokinetics of 111In-DOTA-GSG-J18
%ID/g
Tissues	30 min	1 h†	1 h-block	2 h‡	4 h
Tumor	1.63 ± 0.68	0.60 ± 0.32	0.31 ± 0.12*	0.18 ± 0.03	0.10 ± 0.02
Blood	2.37 ± 0.94	0.40 ± 0.24	0.23 ± 0.11	0.03 ± 0.03	0.19 ± 0.02
Heart	0.67 ± 0.27	0.13 ± 0.08	0.07 ± 0.03	0.02 ± 0.01	0.05 ± 0.01
Lung	2.42 ± 0.48	1.06 ± 0.82	0.83 ± 0.19	0.49 ± 0.36	0.62 ± 0.32
Liver	1.42 ± 0.37	0.51 ± 0.48	0.37 ± 0.02	0.23 ± 0.11	0.84 ± 0.13
Spleen	1.77 ± 0.46	0.68 ± 1.01	0.16 ± 0.03	0.19 ± 0.24	1.58 ± 0.36
Stomach	0.36 ± 0.14	0.11 ± 0.04	0.08 ± 0.03	0.04 ± 0.02	0.04 ± 0.00
Large intestine	0.34 ± 0.17	0.15 ± 0.05	0.07 ± 0.02	0.27 ± 0.06	0.28 ± 0.19
Small intestine	0.63 ± 0.29	0.32 ± 0.11	0.15 ± 0.04	0.15 ± 0.08	0.06 ± 0.01
Intestines	0.49 ± 0.22	0.25 ± 0.08	0.12 ± 0.03	0.20 ± 0.07	0.15 ± 0.08
Kidneys	6.71 ± 3.08	2.70 ± 0.95	1.98 ± 0.29	1.67 ± 0.43	1.75 ± 0.17
Brain	0.09 ± 0.03	0.03 ± 0.01	0.02 ± 0.00	0.01 ± 0.00	0.01 ± 0.00
Muscle	0.32 ± 0.17	0.06 ± 0.03	0.04 ± 0.01	0.01 ± 0.00	0.01 ± 0.00
Pancreas	0.65 ± 0.18	0.11 ± 0.05	0.08 ± 0.01	0.02 ± 0.01	0.04 ± 0.01
Bone	0.31 ± 0.13	0.06 ± 0.05	0.05 ± 0.03	0.02 ± 0.01	0.08 ± 0.02
Skin	1.28 ± 0.68	0.22 ± 0.11	0.22 ± 0.08	0.09 ± 0.03	0.10 ± 0.01
Uptake ratio
Tumor to blood	0.69	1.50	1.35	6.00	0.53
Tumor to muscle	5.10	10.00	7.75	18.00	10.00

Data are represented as %ID/g (mean ± SD), or as uptake ratio of tumor to normal tissue for female nude mice (n=4) bearing SKOV-3 xenografted tumors. Mice were sacrificed at different times post-injection of ¹¹¹In-DOTA-GSG-J18.

^†n=7;

^‡n=5;

^*p=0.03; significant difference between tumor uptake of radiolabeled peptide 1 h post-injection with and without the presence of its non-radioactive counterpart.