Table 1. HIV-specific T cell immune responses in the 38 infants who received the full set of ALVAC vaccinations and all placebo recipients.
Birth | Week 10 | Month 24 | |||||||
---|---|---|---|---|---|---|---|---|---|
Placebo (%) | ALVAC (%) | Pa | Placebo (%) | ALVAC (%) | Pa | Placebo (%) | ALVAC (%) | Pa | |
CD4b ICS | 0/11 (0) | 0/33 (0) | -- | 2/9 (22.2) | 2/38 (5.3) | 0.16 | 1/9 (11.1) | 6/36 (16.7) | 1.00 |
CD4c CFSE | 0/11 (0) | 2/34 (5.9) | 1.00 | 0/7 (0) | 9/31 (29.0) | 0.16 | 0/7 (0) | 0/30 (0) | -- |
CD8b ICS | 0/11 (0) | 0/33 (0) | -- | 1/9 (11.1) | 1/38 (2.6) | 0.35 | 0/9 (0) | 5/36 (13.9) | 0.57 |
CD8c CFSE | 0/11 (0) | 1/34 (2.9) | 1.00 | 0/7 (0.0) | 3/31 (9.7) | 1.00 | 0/7 (0) | 0/30 (0) | - |
P-values from two-sided Fisher's Exact test
Effector assay: Intracellular cytokine and/or CD107
CFSE proliferation