Gurwitz 2008.

Study characteristics
Methods	Cluster RCT
Participants	Academic long‐term care facilities, Canada and USA 1118 patients, 29 units, 2 facilities
Interventions	CDSS linked with CPOE intended to prevent adverse drug events by flagging serious drug‐drug interactions and high‐risk prescriptions
Outcomes	Clinical endpoint (preventable adverse drug events)
Co‐Interventions	Educational: None Beyond Clinician Education: None
CDSS Features ‐ Acknowledgement of CDSS Required	Not reported
CDSS Features ‐ Other	Considered alert fatigue in design, conveyed patient‐specific information, interruptive, 'push' mode of delivery, targeted overuse
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	N/A
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	N/A
Baseline characteristics similar?	Unclear risk	N/A
Unit of analysis error	Unclear risk	N/A