Spirk 2017.

Study characteristics
Methods	RCT
Participants	General internal medicine wards, academic health center, Switzerland (University Hospital Bern) 1593 patients
Interventions	Prompted clinicians to evaluate pulmonary embolism risk using risk calculator and recommended thromboprophylaxis for patients at high‐risk
Outcomes	Process adherence (other), Clinical endpoint (mortality, venous thromboembolism, bleeding)
Co‐Interventions	Educational: None Beyond Clinician Education: None
CDSS Features ‐ Acknowledgement of CDSS Required	Yes ‐ required acknowledgement of the CDSS and documentation of action taken
CDSS Features ‐ Other	Ambush, considered alert fatigue in design, developed by study investigators, interruptive, makes care recommendation, 'push' mode of delivery, targeted overuse and underuse
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	N/A
Baseline characteristics similar?	Low risk