| Methods |
Method of randomisation was not described. Sealed envelopes were used to conceal treatment allocation. Blinding was not described. |
| Participants |
62 patients undergoing elective hepatic resection were randomly allocated to 1 of 2 groups:
(1) Fibrin sealant group (n = 31), M/F = 25/6, mean age (+/‐SD) = 63 (8) years.
(2) Control group (n = 31), M/F = 23/8, mean age (+/‐SD) age = 60 (9) years. |
| Interventions |
(1) Fibrin sealant group: during parenchymal dissection in major and minor resections, vessels and bile ducts were hemo‐clipped or ligated meticulously. Small surgical bleeding and haemorrhage from the vessels withdrawn into the parenchyma were managed with mattress sutures, with or without electrocauterisation. After those procedures, soft sterile paper was placed on the cut surface to measure the cut area. FS (Beriplast P®) was then applied onto the cut surface of the liver using a syringe.
(2) Control group: the cut surface of the liver was treated with microcrystalline collagen powder (Avitene®). The wound was then pressed tightly with a gauze sponge every 5 minutes. |
| Outcomes |
Blood loss (ml) ‐ 24 hours post‐operative.
Blood loss (ml) ‐ total blood loss.
Blood loss (ml) ‐ intra‐operative.
Intra‐operative haemostatic efficacy.
Bile leakage (n).
Post‐operative re‐bleeding (n).
Complications (n).
Mortality (n).
Wound infection (n). |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Method of randomisation was not reported |
| Allocation concealment? |
High risk |
C ‐ Inadequate (sealed envelopes) |
| Blinding?
All outcomes |
Unclear risk |
Not reported |
