| Methods |
Methods of randomisation and allocation concealment were not described. |
| Participants |
40 patients undergoing elective liver resection were randomly allocated to 1 of 2 groups:
(1) Fibrin sealant group (n = 20), M/F = 19/1, mean age (+/‐SD) = 55 (13.7) years.
(2) Control group (n = 20), M/F = 18/2, mean age (+/‐SD) = 64.5 (9.8) years. |
| Interventions |
(1) Fibrin sealant group: at the end of liver resection, when the bleeding had been checked, the raw surface area was measured by first applying a gauze over the cut surface, then measuring the blood tinged gauze. FS was then applied to the raw surface by means of a double‐barrelled syringe then the wound was closed with a Jackson‐Pratt closed system drain left in the subphrenic or subhepatic space.
(2) Control group: received no FS treatment. |
| Outcomes |
Blood loss (ml) ‐ intra‐operative blood loss.
Blood loss (g) ‐ estimated post‐operative blood loss.
Drainage (days).
Secondary bleeding (n).
Pleural effusion (n).
Bile leakage (n).
Wound infection (n). |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Method of randomisation was not reported |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
| Blinding?
All outcomes |
High risk |
Outcomes assessment was not blinded |
