| Methods |
Method of randomisation and allocation concealment were not described. Blinding was not described. |
| Participants |
82 patients undergoing elective liver resection were randomly allocated to 1 of 2 groups:
(1) Fibrin sealant group (n = 38), M/F = 24/14, mean age (+/‐SD) = 52 (15) years
(2) Control group (n = 44), M/F = 20/24, mean age (+/‐SD) = 49 (15) years |
| Interventions |
(1) Fibrin sealant group: liver transection was performed using Kelly forceps and ultrasonic dissector, which isolated vascular and biliary radicles. Haemostasis was secured by sutures and clips. At peritoneal closure after the completion of haemostasis and biliostasis, a single dose of FS (Biocol®) was applied to the liver cut surface. A silicone rubber closed‐system drain was placed in the empty space created by the removal of the liver parenchyma.
(2) Control group: received no fibrin sealant treatment. |
| Outcomes |
Number of patients exposed to allogeneic blood transfusion (n).
Amount of allogeneic blood transfused (units).
Total fluid drainage (ml) ‐ 72 hours post‐operative.
Infection (n).
Hb and bilirubin concentration of fluid drainage.
Length of hospital stay (days).
Operation time (hours).
Ascites (n).
Subphrenic collections (n).
Pulmonary complications (n). |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Method of randomisation was not reported |
| Allocation concealment? |
Unclear risk |
B ‐ Unclear |
| Blinding?
All outcomes |
Unclear risk |
Not reported |
