| Methods |
Randomisation was performed using sealed envelopes and was stratified to include similar numbers of cirrhotic patients in each study. Data were analysed on the intention‐to‐treat principle. |
| Participants |
300 patients undergoing elective hepatectomy were randomly allocated to 1 of 2 groups:
(1) Fibrin sealant group (n = 150), M/F = 59/91, mean age (+/‐SD) = 62 (11) years.
(2) Control group (n = 150), M/F = 46/104, mean age (+/‐SD) = 60 (11) years. |
| Interventions |
(1) Fibrin sealant group received 5 mls of Tissucol® in aerosolised form on the raw surface of the liver with an absorbable collagen sponge also applied with manual pressure after spraying the glue.
(2) Control group received neither the fibrin sealant nor the collagen sponge. |
| Outcomes |
Number of patients exposed to allogeneic blood transfusion (n).
Amount of allogeneic blood transfused (units).
Blood loss. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Method of randomisation was not reported |
| Allocation concealment? |
High risk |
C ‐ Inadequate (sealed envelopes were used) |
| Blinding?
All outcomes |
Unclear risk |
Not reported |
