1. Summary of outcomes: analgesia and use of rescue medication.
| Analgesia | Rescue medication | |||||
| Study ID | Treatment | PI or PR | Number with 50% PR | PGE: v good or excellent | Median time to use (h) | % using |
| Ahlstrom 1993 | (1) Ibuprofen 400 mg, n = 32 (3) Placebo n = 30 |
SPID 6:
(1) 188 mm (3) 32 mm |
(1) 19/32 (3) 2/30 |
at 6 h: (1) 75% (3) 17% |
No data | at 6 h: (1) 31 (3) 77 |
| Arnold 1990 | (1) Ibuprofen 400 mg, n = 15 (2) Ketoprofen 25 mg, n = 14 (3) Ketoprofen 100 mg, n = 16 (4) Placebo, n = 14 |
TOTPAR 6: (1) 4.2 (4) 1.5 |
(1) 2/15 (4) 0/14 |
No usable data | Mean: (1) 3.9 (4) 2.4 |
at 6 h: (1) 67 (4) 83 |
| Bakshi 1994 | (1) Ibuprofen 400 mg, n = 80 (2) Diclofenac (dispersible) 50 mg, n = 83 (3) Placebo, n = 82 |
TOTPAR 6: (1) 14.9 (3) 8.9 |
(1) 57/80 (3) 31/82 |
No usable data | Mean: (1) 5.3 (3) 3.4 |
at 6 h: (1) 28 (3) 65 |
| Black 2002 | (1) Ibuprofen 200 mg, n = 100 (2) Ibuprofen 400 mg, n = 100 (3) Ibuprofen arginate 200 mg, n = 100 (4) Ibuprofen arginate 400 mg, n = 99 (5) Placebo, n = 99 |
TOTPAR 6:
(1) 12.6 (2) 14.9 (3) 13.1 (4) 15.0 (5) 6.9 |
(1) 58/100 (2) 71/100 (3) 61/100 (4) 71/99 (5) 26/99 |
No usable data | (1) 4.2 (2) 5.2 (3) 4.0 (4) 4.5 (5) 1.3 |
No data |
| Cheung 2007 | (1) Ibuprofen 440 mg, n = 57 (2) Celecoxib 400 mg, n = 57 (3) Placebo, n = 57 |
TOTPAR 6: (1) 14.9 (3) 3.7 |
(1) 40/57 (3) 5/57 |
No data | (1) 11 (3) 1.9 |
at 24 h: (1) 72 (3) 86 |
| Cooper 1977 | (1) Ibuprofen 200 mg n = 38 (2) Ibuprofen 400 mg, n = 40 (3) Aspirin 325 mg, n = 37 (4) Aspirin 650 mg, n = 37 (5) Placebo, n= 40 |
TOTPAR 4: (1) 7.32 (2) 6.27 (5) 3.32 |
(1) 17/38 (2) 20/40 (5) 6/40 |
No data | No data | No data |
| Cooper 1982 | (1) Ibuprofen 400 mg, n =38 (2) Ibuprofen 400 mg + Codeine 60 mg, n = 41 (3) Aspirin 650 mg, n = 38 (4) Aspirin 650 mg + codeine 60 mg, n = 45 (5) Codeine 60 mg, n = 41 (6) Placebo, n = 46 |
TOTPAR 4: (1) 8.4 (6) 2.7 |
(1) 22/38 (2) 27/41 (6) 5/46 |
No usable data | Mean: (1) 3.8 (6) 2.4 |
No data |
| Cooper 1988a | (1) Ibuprofen 400 mg, n = 37 (2) Ketoprofen 100 mg, n = 39 (3) Ketoprofen 25 mg, n = 42 (4) Placebo, n = 43 |
TOTPAR 6: (1) 11.3 (4) 4.7 |
(1) 19/37 (4) 6/43 |
at 6 h: (1) 12/37 (4) 2/43 |
(1) 4.0 (4) 3.0 |
at 6 h: (1) 65 (4) 79 |
| Cooper 1989 | (1) Ibuprofen 400 mg, n = 61 (2) Paracetamol 1000 mg, n = 59 (3) Placebo, n = 64 |
TOTPAR 6: (1) 13.1 (3) 4.7 |
(1) 37/61 (3) 9/64 |
at 6 h: (1) 32/61 (3) 4/64 |
(1) 5.5 (3) 2.3 Mean: (1) 4.5 (3) 3.3 |
at 6 h: (1) 52 (3) 78 |
| Cooper 1996a | (1) Ibuprofen 200 mg, n = 19 (2) Misoprostal 200 mg, n = 18 (3) Ibuprofen 200 mg + misoprostal 200 mg, n = 20 (4) Placebo, n = 13 |
TOTPAR 6: (1) 5.3 (3) 5.1 (4) 1.2 |
(1) 3/19 (3) 3/18 (4) 0/33 |
No usable data | Mean: (1) 3.0 (3) 2.8 (4) 1.8 |
No data |
| De Miguel Rivero 1997 | (1) Ibuprofen arginine 400 mg, n = 36 (2) Magnesic dipyrone, 2 g (IM), n = 33 (3) Placebo, n = 34 |
VAS SPID 5: (1) 187 mm (3) 120 mm |
(1) 24/36 (3) 15/34 |
at 5 h: (1) 20/36 (3) 7/34 |
Mean: (1) 3.5 (3) 1.8 |
at 5 h: (1) 14 (3) 12 |
| Desjardins 2002 | (1) Ibuprofen 200 mg, n = 50 (2) Ibuprofen 400 mg, n = 52 (3) Ibuprofen arginine 200 mg, n = 49 (4) Ibuprofen arginine 400 mg, n = 50 (5) Placebo, n = 24 |
TOTPAR 6: (1) 5.4 (2) 7.3 (3) 5.8 (4) 7.9 (5) 1.7 |
(1) 9/50 (2) 15/52 (3) 10/49 (4) 16/49 (5) 0/23 |
No data | (1) 2.6 (2) 4.0 (3) 3.0 (4) 4.0 (5) 1.5 |
No data |
| Dionne 1998 | (1) S(+)‐Ibuprofen 200 mg, n = 51 (2) S(+)‐Ibuprofen 400 mg, n = 50 (3) Ibuprofen (racemic) 400 mg, n = 50 (4) Placebo, n = 25 |
TOTPAR 6: (1) 13.0 (2) 14.9 (3) 11.5 (4) 3.5 |
(1) 31/51 (2) 35/40 (3) 26/50 (4) 2/25 |
No data | (1) 5.8 (2) 6.1 (3) 5.4 (4) 1.8 |
No data |
| Ehrich 1999 | (1) Ibuprofen 400 mg, n = 20 (2) Rofecoxib 50 mg, n = 32 (3) Rofecoxib 500 mg, n = 20 (4) Placebo, n = 32 |
TOTPAR 6: (1) 15.1 (4) 2.7 |
(1) 14/20 (4) 1/32 |
No usable data | (1) >6 (4) 1.6 |
No usable data |
| Forbes 1984 | (1) Ibuprofen 400 mg, n = 28 (2) Fendosal 200 mg, n = 29 (3) Aspirin 650 mg, n = 24 (4) Placebo n = 28 |
TOTPAR 6: (1) 15.8 (4) 3.8 |
(1) 21/28 (4) 3/28 |
No usable data | (1) 8.3 (4) 2.7 Mean: (1) 8.5 (4) 4.5 |
at 12 h: (1) 75 (4) 89 |
| Forbes 1990 | (1) Ibuprofen 400 mg, n = 32 (2) Ketorolac 10 mg, n = 31 (3) Ketorolac 20 mg, n = 35 (4) Paracetamol 600 mg, n = 36 (5) Paracetamol 600 mg + codeine 60 mg, n = 38 (6) Placebo, n = 34 |
TOTPAR 6: (1) 10.5 (6) 1.9 |
(1) 15/32 (6) 0/34 |
No usable data | (1) 4.7 (6) 1.9 Mean: (1) 4.6 (6) 2.9 |
at 6 h: (1) 58 (6) 97 |
| Forbes 1991a | (1) Ibuprofen 50 mg, n = 57 (2) Ibuprofen 100 mg, n = 49 (3) Ibuprofen 200 mg, n = 48 (4) Ibuprofen 100 mg + Caffeine 100 mg, n = 49 (5) Ibuprofen 200 mg + Caffeine 100 mg, n = 44 (6) Placebo n = 51 |
TOTPAR 6: (1) 7.0 (2) 7.0 (3) 8.7 (4) 9.3 (5) 12.6 (6) 2.2 |
(1) 16/57 (2) 13/49 (3) 18/48 (4) 19/49 (5) 26/44 (6) 0/51 |
No usable data | Mean: 1) 4.9 (2) 4.8 (3) 5.1 (4) 5.4 (5) 6.1 (6) 3.0 |
at 8 h: (1) 79 (2) 78 (3) 79 (4) 69 (5) 57 (6) 94 |
| Forbes 1991b | (1) Ibuprofen 400 mg, n = 37 (2) Bromfenac 5 mg, n = 39 (3) Bromfenac 10 mg, n = 43 (4) Bromfenac 25 mg, n = 42 (5) Aspirin 650 mg, n = 41 (6) Placebo, n = 39 |
TOTPAR 6: (1) 11.0 (6) 2.5 |
(1) 18/37 (6) 3/39 |
No usable data | (1) 6.9 (6) 1.8 Mean: (1) 5.7 (6) 2.8 |
at 6 h: (1) 42 (6) 96 at 8 h: (1) 57 (6) 97 |
| Forbes 1992 | (1) Ibuprofen 400 mg, n = 38 (2) Bromfenac 10 mg, n = 43 (3) Bromfenac 25 mg, n = 41 (4) Bromfenac 50 mg, n = 42 (5) Bromfenac 100 mg, n = 40 (6) Aspirin 650 mg, n = 38 (7) Placebo, n = 38 |
TOTPAR 6: (1) 11.8 (7) 2.1 |
(1) 20/38 (7) 0/38 |
No usable data | (1) 7.3 (7) 1.8 Mean: (1) 6.3 (7) 2.7 |
at 6 h: (1) 38 (7) 92 at 8 h: 1) 58 (7) 97 |
| Frame 1989 | (1) Ibuprofen 400 mg, n = 42 (2) Dihydrocodeine 30 mg, n = 43 (3) Placebo, n = 38 |
TOTPAR 5: (1) 11.1 (3) 1.9 |
(1) 26/42 (3) 0/38 |
No data | No usable data | at 5 h: (1) 40 (3) 89 |
| Fricke 1993 | (1) Ibuprofen 400 mg, n = 81 (2) Naproxen Na 440 mg, n = 81 (3) Placebo, n = 39 |
TOTPAR 6: (1) 10.9 (3) 2.9 |
(1) 40/81 (3) 2/39 |
No usable data | (1) 6.0 (3) 1.1 |
at 12 h: (1) 78 (3) No data |
| Gay 1996 | (1) Ibuprofen 400 mg, n = 41 (2) DKP.TRIS 5 mg, n = 41 (3) DKP.TRIS 10 mg, n = 42 (4) DKP.TRIS 20 mg, n = 41 (5) Placebo, n = 39 |
TOTPAR 6: (1) 13.6 (5) 5.2 |
(1) 26/41 (5) 7/39 |
No usable data | Mean: (1) 5.04 (5) 3.65 |
at 6 h: (1) 27 (5) 67 |
| Heidrich 1985 | (1) Ibuprofen 400 mg, n = 40 (2) Paracetamol 300 + codeine 30 mg, n = 40 (3) Placebo, n = 40 |
VAS TOTPAR 6: (1) 234 mm (3) 104 mm |
(1) 15/40 (3) 5/40 |
No data | No data | No data |
| Hersch 1993a | (1) Ibuprofen 200 mg, n = 51 (2) Ibuprofen 400 mg, n = 49 (3) Meclofenamate 100 mg, n = 52 (4) Meclofenamate 50 mg, n = 51 (5) Placebo, n = 51 |
TOTPAR 6: (1) 10.3 (2) 8.0 (5) 1.7 |
(1) 17/51 (2) 22/49 (5) 0/51 |
at 8 h: (1) 24/51 (2) 14/49 (5) 6/51 |
Mean: (1) 3.1 (2) 4.2 (5) 1.5 |
at 8 h: (1) 94 (2) 94 (5) 98 |
| Hersch 1993b | (1) Ibuprofen 400 mg, n = 12 (2) Codeine 60 mg, n = 16 (3) Placebo, n = 16 |
TOTPAR 6: (1) 15.7 (3) 9.0 |
(1) 9/12 (3) 6/16 |
No usable data | Mean: (1) 5.0 (3) 4.0 |
No data |
| Hersh 2000 | (1) Ibuprofen liquigel 200 mg, n = 61 (2) Ibuprofen liquigel 400 mg, n = 59 (3) Paracetamol 1000 mg, n = 63 (4) Placebo, n = 27 |
TOTPAR 6: (1) 14.7 (2) 16.6 (4) 5.2 |
(1) 43/61 (2) 47/59 (4) 5/27 |
at 6 h: (1) 38/61 (2) 41/59 (4) 4/27 |
(1) > 6 (2) > 6 (4) 1.6 |
at 6 h: (1) 31 (2) 23 (4) 75 |
| Hill 2001 | (1) Ibuprofen 400 mg, n = 49 (2) Pregabalin 50 mg, n = 49 (3) Pregabalin 300 mg, n = 50 (4) Placebo, n = 50 |
TOTPAR 6: (1) 10.1 (4) 3.8 |
(1) 22/49 (4) 5/50 |
No usable data | (1) 4.1 (4) 2.0 |
at 6 h: (1) 61 (4) 81 |
| Jain 1986 | (1) Ibuprofen 100 mg, n = 39 (2) Ibuprofen 200 mg, n = 47 (3) Ibuprofen 400 mg, n = 49 (4) Aspirin 650 mg, n = 45 (5) Placebo, n = 47 |
SPID 6: (1) 1.5 (2) 2.3 (3) 3.0 (5) ‐1.7 |
(1) 3/39 (2) 7/47 (3) 9/49 (5) 0/47 |
No usable data | Mean: (1) 3.9 (2) 4.2 (3) 4.0 (5) 2.1 |
at 6 h: (1) 74 (2) 67 (3) 59 (5) 96 |
| Jain 1988 | (1) Ibuprofen 400 mg, n = 49 (2) Ibuprofen 200 mg + caffeine 100 mg, n = 50 (3) Placebo, n = 48 |
TOTPAR 6: (1) 14.4 (2) 13.9 (3) 8.6 |
(1) 33/49 (2) 33/50 (3) 17/48 |
No usable data | No data | at 6 h: (1) 20 (2) 24 (3) 49 |
| Johnson 1997 | (1) Ibuprofen 400 mg, n = 48 (2) Paracetamol 650 mg + oxycodone 10 mg, n = 47 (3) Bromfenac 100 mg, n = 48 (4) Bromfenac 50 mg, n = 47 (5) Placebo, n = 48 |
TOTPAR 6: (1) 7.7 (5) 5.5 |
(1) 15/48 (5) 9/48 |
No usable data | (1) 3.4 (5) 2.7 |
at 6 h: (1) 79 (5) 89 |
| Kiersch 1993 | (1) Ibuprofen 200 mg, n = 81 (2) Naproxen Na 220 mg, n = 80 (3) Placebo, n = 42 |
TOTPAR 6: (1) 10.3 (3) 3.7 |
(1) 37/81 (3) 4/42 |
at 12 h: (1) 34/81 (3) 4/42 |
(1) 8.0 (3) 2.0 |
at 12 h: (1) 63 (3) 90 |
| Laska 1986 | (1) Ibuprofen 400 mg, n = 39 (2) Ibuprofen 600 mg, n = 36 (3) Ibuprofen 800 mg, n = 39 (4) Aluminium ibuprofen 400 mg, n = 39 (5) Placebo, n = 37 |
SPID 6: (1) 13.9 (2) 14.1 (3) 13.4 (5) 5.3 |
(1) 39/39 (2) 36/36 (3) 39/39 (5) 14/37 |
No data | No data | No usable data |
| Laveneziana 1996 | (1) Ibuprofen arginine soluble 400 mg, n = 42 (2) Ketorolac 30 mg, n = 41 (3) Placebo, n = 41 |
VAS SPID 6: (1) 233 mm (3) 204 mm |
(1) 29/42 (3) 24/41 |
No usable data | (1) 1.2 (3) 1.2 |
at 6 h: (1) 36 (3) 41 |
| Malmstrom 1999 | (1) Ibuprofen 400 mg, n = 46 (2) Rofecoxib 50 mg, n = 90 (3) Celecoxib 200 mg, n = 91 (4) Placebo, n = 45 |
TOTPAR 6: (1) 15.2 (4) 3.7 |
(1) 33/46 (4) 4/45 |
No usable data | (1) 8.9 (4) 1.5 |
at 24 h: (1) 76 (4) 91 |
| Malmstrom 2002 | (1) Ibuprofen 400 mg, n = 45 (2) Rofecoxib 50 mg, n = 151 (3) Celecoxib 400 mg, n = 151 (4) Celecoxib 200 mg, n = 90 (5) Placebo, n = 45 |
TOTPAR 6: (1) 11.7 (5) 1.0 |
(1) 24/45 (5) 0/45 |
No usable data | (1) 10.0 (5) 1.6 |
at 24 h: (1) 87 (5) 98 |
| Malmstrom 2004 | (1) Ibuprofen 400 mg, n = 48 (2) Etoricoxib 60 mg, n = 75 (3) Etoricoxib 120 mg, n = 76 (4) Etoricoxib 180 mg, n = 74 (5) Etoricoxib 240 mg, n = 76 (6) Placebo, n = 49 |
TOTPAR 6: (1) 14.1 (6) 3.4 |
(1) 32/48 (6) 4/49 |
No usable data | (1) 10.1 (6) 2.1 |
at 24 h: (1) 81 (6) 82 |
| McQuay 1996 | (1) Ibuprofen 200 mg, n = 31 (2) Ibuprofen 400 mg, n = 30 (3) Ibuprofen 200 mg + caffeine 50 mg, n = 30 (4) Ibuprofen 200 mg + caffeine 100 mg, n = 30 (5) Ibuprofen 200 mg + caffeine 200 mg, n = 29 (6) Placebo, n = 11 |
TOTPAR 6: (1) 3.0 (2) 7.0 (3) 10.3 (4) 9.5 (5) 5.5 (6) 0 |
(1) 2/31 (2) 6/30 (3) 8/30 (4) 14/30 (5) 12/29 (6) 0/11 |
No usable data | No data | No data |
| Medve 2001 | (1) Ibuprofen 200 mg, n = 240 (2) Tramadol 37.5 mg, n = 238 (3) Paracetamol 325 mg, n = 240 (4) Tramadol 37.5 mg + paracetamol 325 mg, n = 240 (5) Placebo, n = 239 |
Data taken from IPMA: (1) 114/240 (5) 5/239 |
No usable data | (1) 5.4 (5) 2.0 |
No data | |
| Mehlisch 1990 | (1) Ibuprofen 400 mg, n = 306 (2) Paracetamol 1000 mg, n = 306 (3) Placebo, n = 85 |
SPID 6: (1) 5.8 (3) 1.2 |
(1) 124/306 (3) 5/85 |
No data | No data | at 6 h: (1) 41 (3) 75 |
| Mehlisch 1995 | (1) Ibuprofen lysine 400 mg, n = 98 (2) Paracetamol 1000 mg, n = 101 (3) Placebo, n = 40 |
TOTPAR 6: (1) 14.4 (3) 2.6 |
(1) 67/98 (3) 1/40 |
at 6 h: (1) 65/98 (3) 1/40 |
(1) > 6 (3) 1.4 |
at 6 h: (1) 26 (3) 88 |
| Mehlisch 2002 | (1) Ibuprofen 200 mg, n = 100 (2) Ibuprofen 400 mg, n = 100 (3) Ibuprofen arginine 200 mg, n = 100 (4) Ibuprofen arginine 400 mg, n = 100 (5) Placebo, n = 100 |
TOTPAR 6: (1) 10.0 (2) 12.4 (3) 13.6 (4) 13.3 (5) 4.5 |
(1) 44/100 (2) 57/100 (3) 64/100 (4) 62/100 (5) 13/100 |
(1) 3.8 (2) 4.2 (3) 4.5 (4) 4.4 (5) 2.3 |
at 4 h: (1) 32 (2) 47 (3) 27 (4) 33 (5) No data |
|
| Morrison 1999 | (1) Ibuprofen 400 mg, n = 51 (2) Rofecoxib 50 mg, n = 50 (3) Placebo, n = 50 |
TOTPAR 6: (1) 9.3 (3) 4.2 |
(1) 20/51 (3) 6/50 |
No usable data | (1) 6.1 (3) 2.4 |
at 24 h: (1) 82 (3) 92 |
| Nelson 1994 | (1) Ibuprofen lysine 200 mg, n = 77 (2) Aspirin 500 mg, n = 65 (3) Placebo, n = 40 |
TOTPAR 6: (1) 12.3 (3) 5.6 |
(1) 44/77 (3) 8/40 |
at 6 h: (1) 39/77 (3) 6/40 |
(1) >6 (3) 2.9 |
at 6 h: (1) 44 (3) 70 |
| Nørholt 1998 | (1) Ibuprofen 400 mg, n = 26 (2) Placebo, n = 31 |
TOTPAR 4: (1) 11.7 (2) 4.5 |
(1) 22/26 (2) 8/31 |
No data | No data | at 4 h: (1) 15 (2) 71 |
| Olson 2001 | (1) Ibuprofen liquigel 400 mg, n = 67 (2) Ketoprofen 25 mg, n = 67 (3) Paracetamol 1000 mg, n = 66 (4) Placebo, n = 39 |
TOTPAR 6: (1) 17.4 (4) 4.3 |
(1) 57/67 (4) 5/39 |
at 6 h: (1) 52/67 (4) 4/49 |
(1) > 6 (4) 1.3 |
at 6 h: (1) 21 (4) 79 |
| Pagnoni 1996 | (1) Ibuprofen arginine soluble 400 mg, n = 30 (2) Ketorolac (IM) 30 mg, n = 30 (3) Placebo, n = 32 |
VAS SPID 6: (1) 279 (3) 114 |
(1) 13/30 (3) 5/32 |
at 6 h: (1) 5/30 (3) 0/32 |
(1) 2.1 (3) 1.9 |
at 6 h: (1) 43 (3) 66 |
| Parker 1986 | (1) Ibuprofen syrup 600 mg, n = 44 (2) Aspirin syrup 600 mg, n = 33 (3) Placebo, n = 33 |
TOTPAR 4: (1) 10.4 (3) 8.8 |
(1) 33/44 (3) 20/33 |
No data | No data | No data |
| Schachtel 1989 | (1) Ibuprofen 400 mg, n = 36 (2) Paracetamol 1000 mg, n = 37 (3) Placebo, n = 38 |
TOTPAR 4: (1) 10.4 (3) 5.5 |
(1) 27/36 (3) 13/38 |
No data | No data | at 4 h: (1) 22 (3) 58 |
| Schou 1998 | (1) Ibuprofen 50 mg, n = 51 (2) Ibuprofen 100 mg, n = 53 (3) Ibuprofen 200 mg, n = 49 (4) Ibuprofen 400 mg, n = 49 (5) Placebo, n = 56 |
TOTPAR 6: (1) 11.8 (2) 11.2 (3) 15.5 (4) 17.2 (5) 7.3 |
(1) 27/51 (2) 27/53 (3) 36/49 (4) 41/49 (5) 16/56 |
No data | (1) 5.5 (2) >6 (3) >6 (4) >6 (5) 3.7 |
Up to 6 h: (1) 54 (2) 48 (3) 36 (4) 16 (5) 66 |
| Schwartz 2007 | (1) Ibuprofen 400 mg, n = 15 (2) MK‐0703 12.5 mg, n = 31 (3) MK‐0703 50 mg, n = 28 (4) MK‐0703 100 mg, n = 31 (5) Placebo, n = 16 |
No data | Not available | at 8 h: (1) 5/15 (5) 0/16 |
(1) 7.1 (5) 1.6 |
at 8 h: (1) 80 (5) 100 |
| Seymour 1991 (study 1) | (1) Ibuprofen tablets 400 mg, n = 31 (2) Ibuprofen liquid in gelatin capsules 400 mg, n = 32 (3) Placebo n = 32 |
VAS SPID 6: (1) 243 mm (2) 233 mm (3) 120 mm |
(1) 20/31 (2) 22/32 (3) 10/32 |
No usable data | Mean: (1) 3.6 (2) 3.5 (3) 2.1 |
at 6 h: (1) 39 (2) 44 (3) 69 |
| Seymour 1991 (study 2) | (1) Ibuprofen tablets 400 mg, n = 30 (2) Ibuprofen soluble 400 mg, n = 32 (3) Placebo, n = 30 |
VAS SPID 6: (1) 214 mm (2) 228 mm (3) 86 mm |
(1) 20/30 (2) 8/30 (3) 7/30 |
No usable data | Mean: (1) 3.24 (2) 3.15 (3) 1.40 |
at 6 h: (1) 60 (2) 72 (3) 93 |
| Seymour 1996 | (1) Ibuprofen tablets 200 mg, n = 18 (2) Ibuprofen soluble 200 mg, n = 17 (3) Ibuprofen tablets 400 mg, n = 15 (4) Ibuprofen soluble 400 mg, n = 16 (5) Ibuprofen tablets 600 mg, n = 17 (6) Ibuprofen soluble 600 mg, n = 17 (7) Placebo, n = 19 |
VAS SPID 6: (1) 230 mm (2) 148 mm (3) 258 mm (4) 238 mm (5) 140 mm (6) 198 mm (7) 44 mm |
(1) 7/18 (2) 9/17 (3) 11/15 (4) 11/16 (5) 11/17 (6) 8/17 (7) 2/19 |
No usable data | (1) 3.0 (2) 1.6 (3) 2.8 (4) 2.1 (5) 2.0 (6) 1.5 (7) 0.8 |
at 6 h: (1) 88 (2) 88 (3) 67 (4) 81 (5) 100 (6) 88 (7) 100 |
| Seymour 1998 | (1) Ibuprofen 400 mg, n = 76 (2) Aceclofenac 150 mg, n = 71 (3) Placebo, n = 70 |
VAS TOTPAR 4: (1) 151 mm (3) 46 mm |
(1) 27/76 (3) 3/70 |
No usable data | (1) 3.5 (3) 1.6 |
at 6 h: (1) 55 (3) 86 |
| Seymour 1999 | (1) Ibuprofen 400 mg, n = 41 (2) WAG 994 1 mg, n = 42 (3) Placebo, n = 39 |
TOTPAR 6: (1) 10.4 (3) 5.1 |
(1) 19/41 (3) 7/39 |
No usable data | (1) 5.2 (3) 2.0 |
at 6 h: (1) 56 (3) 100 |
| Seymour 2000 | (1) Ibuprofen 200 mg, n = 59 (2) Buffered ketoprofen 12.5 mg, n = 61 (3) Placebo, n = 60 |
TOTPAR 6: (1) 6.4 (3) 4.1 |
(1) 14/59 (3) 7/60 |
No usable data | (1) 2.0 (3) 1.9 |
at 6 h: (1) 83 (3) 98 |
| Singla 2005 | (1) Ibuprofen 400 mg, n = 175 (2) Ibuprofen 400 mg + oxycodone 5 mg, n = 169 (3) Oxycodone 5 mg, n = 52 (4) Placebo, n = 60 |
TOTPAR 6: (1) 10.0 (4) 6.4 |
(1) 77/175 (4) 14/60 |
No usable data | (1) 4.0 (4) 2.3 |
at 6 h: (1) 71 (4) No data |
| Sunshine 1983 | (1) Ibuprofen 400 mg, n = 30 (2) Aspirin 600 mg, n = 30 (3) Zomepirac 100 mg, n = 30 (4) Placebo, n = 30 |
SPID 4: (1) 6.0 (4) 1.0 |
(1) 21/30 (4) 3/30 |
No data | No data | at 4 h: (1) 0 (4) 17 |
| Sunshine 1987 | (1) Ibuprofen 400 mg, n = 38 (2) Ibuprofen 200 mg + codeine 30 mg, n = 40 (3) Ibuprofen 400 mg + codeine 60 mg, n = 40 (4) Codeine 60 mg, n = 37 (5) Placebo, n = 40 |
SPID 4: (1) 4.8 (5) 3.4 |
(1) 16/38 11/40 |
No usable data | No usable data | at 4 h: (1) 13 (5) 50 |
| Sunshine 1996 | (1) Ibuprofen 50 mg, n = 51 (2) Ibuprofen 100 mg, n = 51 (3) Ibuprofen 200 mg, n = 50 (4) Ibuprofen 100 mg + caffeine 100 mg, n = 50 (5) Ibuprofen 200 mg + caffeine 100 mg, n = 50 (6) Placebo, n = 50 |
TOTPAR 6: (1) 4.7 (2) 8.2 (3) 13.9 (4) 10.9 (5) 14.9 (6) 2.2 |
(1) 7/51 (2) 17/51 (3) 33/50 (4) 24/50 (5) 36/50 (6) 0/50 |
No usable data | No data | at 6 h: (1) 4 (2) 0 (3) 0 (4) 0 (5) 2 (6) 32 |
| Sunshine 1997 | (1) Ibuprofen 400 mg, n = 40 (2) Ibuprofen 400 mg + hydrocodone 15 mg, n = 40 (3) Placebo, n = 39 |
TOTPAR 6: (1) 9.7 (3) 2.7 |
(1) 17/40 (3) 1/39 |
No usable data | No usable data | at 6 h: (1) 25 (3) 82 |
| Sunshine 1998 | (1) Ibuprofen 200 mg, n = 35 (2) Ketoprofen 6.25 mg, n = 35 (3) Ketoprofen 12.5 mg, n = 35 (4) Ketoprofen 25 mg, n = 35 (5) Placebo, n = 35 |
TOTPAR 6: (1) 12.5 (5) 3.6 |
(1) 20/35 (5) 3/35 |
No usable data | No usable data | No usable data |
| Unpublished from Edwards 2002 | (1) Ibuprofen 400 mg, n = 339 (2) Placebo, n = 339 |
Individual patient meta‐analysis | (1) 145/339 (2) 11/339 |
No usable data | No usable data | at 8 h: (1) 43/339 (2) 121/337 |
| Van Dyke 2004 | (1) Ibuprofen 400 mg, n = 186 (2) Ibuprofen 400 mg + oxycodone 5 mg, n = 187 (3) Oxycodone 5 mg, n = 63 (4) Placebo, n = 62 |
TOTPAR 6: (1) 12.9 (4) 4.8 |
(1) 112/186 (4) 9/62 |
No usable data | 1) > 6 (4) 2.0 |
at 6 h: (1) 38 (4) 84 |
| Wahl 1997 | (1) Ibuprofen lysinate 342 mg (= 200 mg Ibu), n = 74 (2) Paracetamol 200 mg + aspirin 250 mg + caffeine 50 mg, n = 73 (3) Placebo, n = 42 |
TOTPAR 6: (1) 11.6 (3) 2.5 |
(1) 39/74 (3) 1/42 |
No usable data | No data | at 6 h: (1) 42 (3) 81 |
| Wideman 1999 (study 1) | (1) Ibuprofen 200 mg, n = 60 (2) Ibuprofen 200 mg, + hydrocodone 7.5 mg, n = 59 (3) Hydrocodone 7.5 mg, n = 61 (4) Placebo, n = 60 |
TOTPAR 6: (1) 4.9 (4) 3.5 |
(1) 9/60 (4) 5/60 |
No data | No data | No data |
| Wideman 1999 (study 2) | (1) Ibuprofen 400 mg, n = 50 (2) Ibuprofen 400 mg + hydrocodone 15 mg, n = 50 (3) Hydrocodone 15 mg, n = 50 (4) Placebo, n = 51 |
TOTPAR 6: (1) 9.7 (4) 3.0 |
(1) 21/50 (4) 3/51 |
No data | (1) 4.2 (4) 1.8 |
at 8 h: (1) 69 (4) 100 |
| Zelenakas 2004 | (1) Ibuprofen 400 mg, n = 51 (2) Lumiracoxib 100 mg, n = 51 (3) Lumiracoxib 400 mg, n = 50 (4) Placebo, n = 50 |
TOTPAR 6: (1) 11.6 (4) 4.2 |
(1) 27/51 (4) 6/50 |
No usable data | (1) ˜8 (4) ˜2 |
at 12 h: (1) 73 (4) 92 |