Comparison 3. Ibuprofen 200 mg versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Participants with at least 50% pain relief over 4 to 6 hours	20	2690	Risk Ratio (M‐H, Fixed, 95% CI)	4.62 [3.85, 5.56]
2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery	20		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Dental surgery	18	2470	Risk Ratio (M‐H, Fixed, 95% CI)	4.48 [3.71, 5.41]
2.2 Other surgery	2	220	Risk Ratio (M‐H, Fixed, 95% CI)	7.73 [3.24, 18.41]
3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation	20		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Standard ibuprofen	17	2103	Risk Ratio (M‐H, Fixed, 95% CI)	6.11 [4.84, 7.73]
3.2 ibuprofen lysine, arginine, or soluble	7	828	Risk Ratio (M‐H, Fixed, 95% CI)	5.73 [4.15, 7.90]
4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation	18		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Standard ibuprofen	15	1883	Risk Ratio (M‐H, Fixed, 95% CI)	5.98 [4.69, 7.62]
4.2 Ibuprofen lysine, arginine or soluble	7	828	Risk Ratio (M‐H, Fixed, 95% CI)	5.73 [4.15, 7.90]
5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size	15		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 40 or more participants	11	1953	Risk Ratio (M‐H, Fixed, 95% CI)	4.56 [3.71, 5.61]
5.2 Fewer than 40 participants	4	229	Risk Ratio (M‐H, Fixed, 95% CI)	5.15 [2.41, 11.00]
6 Participants using rescue medication over 6 hours	8	794	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.57, 0.70]
7 Participants using rescue medication over 6 hours, dental surgery	7	694	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.60, 0.73]
8 Participants using rescue medication over 6 hours, dental surgery: formulation	7		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 Standard ibuprofen	4	345	Risk Ratio (M‐H, Fixed, 95% CI)	0.74 [0.66, 0.84]
8.2 Ibuprofen lysine, arginine or soluble	4	349	Risk Ratio (M‐H, Fixed, 95% CI)	0.57 [0.48, 0.68]
9 Participants with any adverse event	14	1808	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.71, 1.02]