Comparison 4. Ibuprofen 400 mg versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Participants with at least 50% pain relief over 4 to 6 hours	57	6475	Risk Ratio (M‐H, Fixed, 95% CI)	3.94 [3.58, 4.35]
2 Participants with at least 50% pain relief over 4 to 6 hours: type of surgery	57		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Dental surgery	45	5428	Risk Ratio (M‐H, Fixed, 95% CI)	4.63 [4.13, 5.20]
2.2 Other surgery	12	1047	Risk Ratio (M‐H, Fixed, 95% CI)	2.18 [1.81, 2.62]
3 Participants with at least 50% pain relief over 4 to 6 hours, all surgery: formulation	57		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Standard ibuprofen	51	5604	Risk Ratio (M‐H, Fixed, 95% CI)	4.64 [4.14, 5.18]
3.2 Ibuprofen lysine, arginine or soluble	12	1124	Risk Ratio (M‐H, Fixed, 95% CI)	3.70 [3.00, 4.56]
4 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: formulation	45		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Standard ibuprofen	42	4772	Risk Ratio (M‐H, Fixed, 95% CI)	5.17 [4.56, 5.87]
4.2 Ibuprofen lysine, arginine or soluble	9	959	Risk Ratio (M‐H, Fixed, 95% CI)	6.55 [4.85, 8.85]
5 Participants with at least 50% pain relief over 4 to 6 hours, dental surgery: study size	29		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 40 or more participants	15	3086	Risk Ratio (M‐H, Fixed, 95% CI)	4.44 [3.80, 5.19]
5.2 Fewer than 40 participants	14	856	Risk Ratio (M‐H, Fixed, 95% CI)	4.06 [3.21, 5.14]
6 Participants using rescue medication over 6 hours	28	2983	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.51, 0.57]
7 Participants using rescue medication over 6 hours, dental surgery	22	2554	Risk Ratio (M‐H, Fixed, 95% CI)	0.52 [0.48, 0.55]
8 Participants using rescue medication over 6 hours, dental surgery: formulation	21		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
8.1 Standard ibuprofen	18	1857	Risk Ratio (M‐H, Fixed, 95% CI)	0.55 [0.51, 0.59]
8.2 Ibuprofen lysine, arginine or soluble	6	449	Risk Ratio (M‐H, Fixed, 95% CI)	0.42 [0.35, 0.50]
9 Participants with any adverse event	36	4865	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.82, 1.04]