Cooper 1988a.

Methods	RCT, DB, single oral dose, 4 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at baseline then hourly up to 4 hours.
Participants	Third molar extraction N = 201 M = 59, F = 102 (161 analysed) Mean age 23 years
Interventions	Ibuprofen 400 mg, n = 37 Ketoprofen 100 mg, n = 39 Ketoprofen 25 mg, n = 42 Placebo, n = 43
Outcomes	PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1 Rescue medication permitted after 1 hour.