Cooper 1989.

Methods	RCT, DB, single oral dose, 3 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 30, 60 mins, then hourly up to 4 hours.
Participants	Third molar extraction N = 194 (184 analysed for efficacy, 190 for safety) M = 51, F = 133 Mean age 23 years
Interventions	Ibuprofen 400 mg, n = 61 Paracetamol 1000 mg, n = 59 Placebo, n = 64
Outcomes	PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1 Rescue medication permitted after 1 hour.