Desjardins 2002.

Methods	RCT, DB, single oral dose, 5 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 5, 10, 20, 30, 45, 60, 90, 120 mins, then hourly up to 6 hours.
Participants	Third molar extraction N = 225 M = 103, F = 122 Mean age 25 years
Interventions	Ibuprofen 200 mg, n = 50 Ibuprofen 400 mg, n = 52 Ibuprofen arginate 200 mg, n = 49 Ibuprofen arginate 400 mg, n = 50 Placebo, n = 24
Outcomes	PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1 Rescue medication (paracetamol plus codeine) permitted after 1.5 hours.