Forbes 1991b.

Methods	RCT, DB, single oral dose, 6 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at baseline, then hourly up to 8 hours
Participants	Third molar extraction N = 276 (241 analysed for efficacy, 269 for safety) M = 100, F = 141 Mean age 23 years
Interventions	Ibuprofen 400 mg, n = 37 Bromfenac 5 mg, n = 39 Bromfenac 10 mg, n = 43 Bromfenac 25 mg, n = 42 Aspirin 650 mg, n = 41 Placebo, n = 39
Outcomes	PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1 Rescue medication permitted after 2 hours.