Frame 1989.

Methods	RCT, DB, single oral dose, 3 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 30, 60 mins, then hourly up to 5 hours
Participants	Third molar extraction N = 139 (123 analysed for efficacy) M = 56, F = 92 Mean age 24 years
Interventions	Ibuprofen 400 mg, n = 42 Dihydrocodeine 30 mg, n = 43 Placebo, n = 38
Outcomes	PI: non‐std 9 point scale PR: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R1, DB1, W1 Rescue medication (2nd dose or active drug if placebo group) permitted after 2 hours.