Hersch 1993a.

Methods	RCT, DB, single oral dose, 5 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 30, 60 mins, then hourly up to 8 hours.
Participants	Third molar extraction N = 254 M/F not given Age 16+ years
Interventions	Ibuprofen 200 mg, n = 51 Ibuprofen 400 mg, n = 49 Meclofenamate 100 mg, n = 52 Meclofenamate 50 mg, n = 51 Placebo, n = 51
Outcomes	PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R1, DB1, W0 Rescue medication permitted after 1 hour.