Jain 1986.

Methods	RCT, DB, single oral dose, 5 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at baseline, then hourly up to 6 hours.
Participants	Third molar extraction N = 241 (227 analysed for efficacy) M = 100, F = 127 Mean age 24 years
Interventions	Ibuprofen 400 mg, n = 49 Ibuprofen 200 mg, n = 47 Ibuprofen 100 mg, n = 39 Aspirin 650 mg, n = 45 Placebo, n = 47
Outcomes	PI: non‐std 4 point scale and 100 mm VAS PR: non‐std 5 point scale PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1 Rescue medication permitted after 1 hr.