McQuay 1996.

Methods	RCT, DB, single oral dose, 6 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed up to 6 hours (time points not specified).
Participants	Third molar extraction N = 161 M = 59, F = 102 Mean age 25 years
Interventions	Ibuprofen 200 mg, n = 31 Ibuprofen 400 mg, n = 30 Ibuprofen 200 mg + caffeine 50 mg, n = 30 Ibuprofen 200 mg + caffeine 100 mg, n = 30 Ibuprofen 200 mg + caffeine 200 mg, n = 29 Placebo, n = 11
Outcomes	PI: std 4 point scale and 100 mm VAS PR: std 5 point scale and 100 mm VAS PGE: std 5 point scale Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1 Rescue medication permitted after 45 mins.