Mehlisch 1995.
Methods | RCT, DB, single oral dose, 3 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90, 120 mins, then hourly up to 6 hours. |
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Participants | Third molar extraction N = 240 (239 analysed for efficacy) M = 85, F = 155 Mean age 25 years |
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Interventions | Ibuprofen lysine 400 mg, n = 98 Paracetamol 1000 mg, n = 101 Placebo, n = 40 |
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Outcomes | PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals |
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Notes | Oxford Quality Score: R2, DB2, W1 Rescue medication permitted after 1 hour (but were encouraged to wait for 4 hrs). |