Seymour 1996.

Methods	RCT, DB, single oral dose, 7 parallel groups Medication administered when baseline pain intensity was at least 30 mm Pain assessed at 0, 10, 20, 30, 45, 60, 75, 90, 120, 150, 180 mins, then hourly up to 6 hours.
Participants	Third molar extraction N = 123 (119 analysed) M = 41, F = 78 age range 18‐40 years
Interventions	Ibuprofen tablets 200 mg, n = 18 Ibuprofen soluble 200 mg, n = 17 Ibuprofen tablets 400 mg, n = 15 Ibuprofen soluble 400 mg, n = 16 Ibuprofen tablets 600 mg, n = 17 Ibuprofen soluble 600 mg, n = 17 Placebo, n = 19
Outcomes	PI: std 100 mm VAS PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1 Rescue medication (paracetamol) permitted.