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. 2009 Jul 8;2009(3):CD001548. doi: 10.1002/14651858.CD001548.pub2

Sunshine 1996.

Methods RCT, DB, single oral dose, 6 parallel groups
Medication administered when baseline pain was of moderate to severe intensity
Pain assessed at 0, 30, 60 mins, then hourly up to 6 hours.
Participants Episiotomy
N = 305
All F
Mean age 23 years
Interventions Ibuprofen 50 mg, n = 51
Ibuprofen 100 mg, n = 51
Ibuprofen 200 mg, n = 50
Ibuprofen 100 mg + caffeine 100 mg, n = 50
Ibuprofen 200 mg + caffeine 100 mg, n = 50
Placebo, n = 50
Outcomes PI: std 4 point scale
PR: std 5 point scale
PGE: non‐std 4 point scale
Numbers of participants using rescue medication
Numbers with any adverse event
Withdrawals
Notes Oxford Quality Score: R1, DB2, W1
Rescue medication permitted after 1 hour.