Van Dyke 2004.

Methods	RCT, DB, single oral dose, 4 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60, 90, 120 mins, then hourly up to 6 hours.
Participants	Third molar extraction N = 498 M = 219, F = 279 Mean age 25 years
Interventions	Ibuprofen 400 mg, n = 186 Ibuprofen 400 mg + oxycodone 5 mg, n = 187 Oxycodone 5 mg, n = 63 Placebo, n = 62
Outcomes	PI: std 4 point scale PR: std 5 point scale PGE: std 5 point scale Numbers of participants using rescue medication Time to use of rescue medication Numbers with any adverse event Withdrawals
Notes	Oxford Quality Score: R2, DB2, W1 Rescue medication permitted after 2 hours.