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. 2009 Jul 8;2009(3):CD001548. doi: 10.1002/14651858.CD001548.pub2

Wideman 1999 (study 1).

Methods RCT, DB, single oral dose, 4 parallel groups
Medication administered when baseline pain was of moderate to severe intensity
Pain assessed at 0, 20, 40, 60, 80, 100, 120, 150, 180 mins, then hourly up to 7 hours.
Participants Abdominal or gynaecological surgery
N = 240
All F
Mean age 39 years
Interventions Ibuprofen 200 mg, n = 60
Ibuprofen 200 mg, + hydrocodone 7.5 mg, n = 59
Hydrocodone 7.5 mg, n = 61
Placebo, n = 60
Outcomes PI: std 4 point scale
PR: std 5 point scale
PGE: std 5 point scale
Numbers with any adverse event
Withdrawals
Notes Oxford Quality Score: R1, DB2, W1
Rescue medication permitted after 1 hour.