Comparison 3.
Chorionic villus sampling versus second trimester amniocentesis
| Outcome or subgroup title | No. of studies | No. of participants | Statistical method | Effect size |
|---|---|---|---|---|
| 1 Not complied with allocated procedure | 4 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 1.1 Transcervical CVS versus amniocentesis | 3 | 4595 | Risk Ratio (M-H, Random, 95% CI) | 0.51 [0.14, 1.87] |
| 1.3 CVS (any route) versus amniocentesis | 1 | 3197 | Risk Ratio (M-H, Random, 95% CI) | 0.66 [0.52, 0.83] |
| 2 Sampling failure | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 2.1 Transervical CVS versus amniocentesis | 1 | 797 | Risk Ratio (M-H, Fixed, 95% CI) | 0.55 [0.26, 1.19] |
| 2.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 3.09 [1.98, 4.82] |
| 3 Multiple insertions | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 3.1 Transcervical CVS versus amniocentesis | 1 | 794 | Risk Ratio (M-H, Fixed, 95% CI) | 3.93 [2.72, 5.68] |
| 3.3 CVS (any route) versus amniocentesis | 1 | 2917 | Risk Ratio (M-H, Fixed, 95% CI) | 4.85 [3.92, 6.01] |
| 4 Second test performed | 4 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 4.1 Transcervical CVS versus amniocentesis | 3 | 4256 | Risk Ratio (M-H, Random, 95% CI) | 19.63 [1.24, 309.90] |
| 4.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Random, 95% CI) | 2.83 [1.94, 4.13] |
| 5 Laboratory failure | 3 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 5.1 Transcervical CVS versus amniocentesis | 2 | 2792 | Risk Ratio (M-H, Fixed, 95% CI) | 22.62 [3.07, 166.89] |
| 5.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 0.77 [0.29, 2.06] |
| 6 All non-mosaic abnormalities | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 6.1 Transcervical CVS versus amniocentesis | 2 | 2667 | Risk Ratio (M-H, Fixed, 95% CI) | 1.12 [0.73, 1.72] |
| 7 True mosaics | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 7.1 Transcervical CVS versus amniocentesis | 1 | 672 | Risk Ratio (M-H, Fixed, 95% CI) | 3.42 [0.14, 83.63] |
| 8 Confined mosaics | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 8.1 Transcervical CVS versus amniocentesis | 1 | 1995 | Risk Ratio (M-H, Fixed, 95% CI) | 5.66 [1.97, 16.24] |
| 9 Maternal contamination | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 9.1 Transcervical CVS versus amniocentesis | 1 | 1991 | Risk Ratio (M-H, Fixed, 95% CI) | 12.30 [3.81, 39.67] |
| 9.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 8.90 [0.48, 165.26] |
| 10 Known false positive after birth | 3 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 10.1 Transcervical CVS versus amniocentesis | 2 | 2627 | Risk Ratio (M-H, Fixed, 95% CI) | 7.30 [2.20, 24.25] |
| 10.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 0.99 [0.06, 15.80] |
| 11 Known false negative after birth | 3 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 11.1 Transcervical CVS versus amniocentesis | 2 | 2627 | Risk Ratio (M-H, Fixed, 95% CI) | 7.84 [0.41, 151.61] |
| 11.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 2.97 [0.12, 72.81] |
| 13 Vaginal bleeding after test | 2 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 13.1 Transcervical CVS versus amniocentesis | 2 | 3193 | Risk Ratio (M-H, Random, 95% CI) | 11.48 [2.58, 51.08] |
| 14 Amniotic leakage after test | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 14.1 Transabdominal CVS vs amniocentesis | 1 | 1485 | Risk Ratio (M-H, Fixed, 95% CI) | 2.53 [0.81, 7.92] |
| 14.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 0.55 [0.18, 1.64] |
| 15 Vaginal bleeding after 20 weeks | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 15.1 Transcervical CVS versus amniocentesis | 1 | 797 | Risk Ratio (M-H, Fixed, 95% CI) | 1.44 [0.62, 3.33] |
| 15.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 0.99 [0.69, 1.42] |
| 16 PROM before 28 weeks | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 16.1 Transcervical CVS versus amniocentesis | 1 | 722 | Risk Ratio (M-H, Fixed, 95% CI) | 4.97 [1.45, 17.03] |
| 16.3 CVS (any route) versus amniocentesis | 1 | 2765 | Risk Ratio (M-H, Fixed, 95% CI) | 1.60 [0.80, 3.17] |
| 17 Antenatal hospital admission | 2 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 17.1 Transcervical CVS versus amniocentesis | 1 | 780 | Risk Ratio (M-H, Fixed, 95% CI) | 1.47 [0.81, 2.68] |
| 17.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 0.90 [0.75, 1.08] |
| 18 Delivery before 37 weeks | 3 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 18.1 Transcervical CVS versus amniocentesis | 2 | 2506 | Risk Ratio (M-H, Random, 95% CI) | 1.29 [0.67, 2.47] |
| 18.3 CVS (any route) versus amniocentesis | 1 | 3189 | Risk Ratio (M-H, Random, 95% CI) | 1.33 [1.13, 1.57] |
| 19 Delivery before 33 weeks | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 19.1 Transcervical CVS versus amniocentesis | 1 | 768 | Risk Ratio (M-H, Fixed, 95% CI) | 2.16 [0.94, 4.94] |
| 20 All known pregnancy loss (including termination of pregnancy) | 5 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 20.1 Transcervical CVS versus amniocentesis | 4 | 6527 | Risk Ratio (M-H, Random, 95% CI) | 1.40 [1.09, 1.81] |
| 20.2 Transabdominal CVS versus amniocentesis | 1 | 2234 | Risk Ratio (M-H, Random, 95% CI) | 0.90 [0.66, 1.23] |
| 20.3 CVS (any route) versus amniocentesis | 2 | 6503 | Risk Ratio (M-H, Random, 95% CI) | 1.43 [1.22, 1.67] |
| 21 Termination of pregnancy (all) | 3 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 21.1 Transcervical CVS versus amniocentesis | 2 | 3454 | Risk Ratio (M-H, Fixed, 95% CI) | 0.88 [0.58, 1.34] |
| 21.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 1.42 [0.96, 2.11] |
| 24 Spontaneous miscarriage | 4 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 24.1 Transcervical CVS versus amniocentesis | 3 | 5506 | Risk Ratio (M-H, Random, 95% CI) | 1.50 [1.07, 2.11] |
| 24.2 Transabdominal CVS versus amniocentesis | 1 | 2069 | Risk Ratio (M-H, Random, 95% CI) | 0.77 [0.49, 1.21] |
| 24.3 CVS (any route) versus amniocentesis | 2 | 6280 | Risk Ratio (M-H, Random, 95% CI) | 1.51 [1.23, 1.85] |
| 25 Spontaneous miscarriage after test | 3 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 25.1 Transcervical CVS versus amniocentesis | 2 | 1579 | Risk Ratio (M-H, Random, 95% CI) | 1.77 [0.28, 11.00] |
| 25.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Random, 95% CI) | 3.46 [2.21, 5.42] |
| 26 Perinatal deaths | 4 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 26.1 Transcervical CVS versus amniocentesis | 3 | 5521 | Risk Ratio (M-H, Fixed, 95% CI) | 1.68 [0.73, 3.84] |
| 26.2 Transabdominal CVS versus amniocentesis | 1 | 2069 | Risk Ratio (M-H, Fixed, 95% CI) | 1.18 [0.40, 3.51] |
| 26.3 CVS (any route) versus amniocentesis | 2 | 6280 | Risk Ratio (M-H, Fixed, 95% CI) | 1.21 [0.65, 2.24] |
| 27 Stillbirths | 3 | Risk Ratio (M-H, Random, 95% CI) | Subtotals only | |
| 27.1 Transcervical CVS versus amniocentesis | 2 | 3454 | Risk Ratio (M-H, Random, 95% CI) | 0.94 [0.02, 45.31] |
| 27.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Random, 95% CI) | 0.99 [0.35, 2.81] |
| 28 Neonatal deaths | 4 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 28.1 Transcervical CVS versus amniocentesis | 3 | 4251 | Risk Ratio (M-H, Fixed, 95% CI) | 1.58 [0.41, 6.06] |
| 28.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 2.64 [0.70, 9.93] |
| 29 All recorded deaths after viability | 3 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 29.1 Transcervical CVS versus amniocentesis | 2 | 1579 | Risk Ratio (M-H, Fixed, 95% CI) | 0.83 [0.24, 2.93] |
| 29.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 1.44 [0.67, 3.09] |
| 30 Congenital anomalies (all recorded) | 4 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 30.1 Transcervical CVS versus amniocentesis | 2 | 1408 | Risk Ratio (M-H, Fixed, 95% CI) | 0.62 [0.24, 1.56] |
| 30.3 CVS (any route) versus amniocentesis | 2 | 3338 | Risk Ratio (M-H, Fixed, 95% CI) | 0.80 [0.66, 0.96] |
| 31 Talipes | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 31.1 Transcervical CVS versus amniocentesis | 1 | 797 | Risk Ratio (M-H, Fixed, 95% CI) | Not estimable |
| 32 Hemangiomas (localised vascular lesions of the skin and subcutaneous tissue) | 1 | 182 | Risk Ratio (M-H, Fixed, 95% CI) | 1.35 [0.81, 2.24] |
| 33 Limb reduction defects | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 4.95 [0.24, 102.97] |
| 33.3 CVS (any route) versus amniocentesis | 1 | 3201 | Risk Ratio (M-H, Fixed, 95% CI) | 4.95 [0.24, 102.97] |
| 38 Result given in less than 7 days (not prespecified) | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 38.3 CVS (any route) versus amniocentesis | 1 | 3099 | Risk Ratio (M-H, Fixed, 95% CI) | 23.52 [12.54, 44.10] |
| 39 Result given in less than 14 days (not prespecified) | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 39.3 CVS (any route) versus amniocentesis | 1 | 3099 | Risk Ratio (M-H, Fixed, 95% CI) | 3.96 [3.17, 4.95] |
| 40 Result given in less than 21 days (not prespecified) | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 40.3 CVS (any route) versus amniocentesis | 1 | 3099 | Risk Ratio (M-H, Fixed, 95% CI) | 0.72 [0.63, 0.82] |
| 41 Result given in more than 21 days (not prespecified) | 1 | Risk Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 41.3 CVS (any route) versus amniocentesis | 1 | 3099 | Risk Ratio (M-H, Fixed, 95% CI) | 0.33 [0.28, 0.39] |
| 42 Not wanting another baby at 22 weeks’ gestation (not prespecified) | 1 | Odds Ratio (M-H, Fixed, 95% CI) | Subtotals only | |
| 42.1 Transcervical CVS versus amniocentesis | 1 | 51 | Odds Ratio (M-H, Fixed, 95% CI) | 0.34 [0.11, 1.09] |