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. 2014 Sep 23;8:167. doi: 10.3389/fnsys.2014.00167

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Copyright © 2014 Salloum, Chen, Velet, Manzoor, Elkin, Kidd, Coughlin, Yurosko, Bou-Anak, Azadi, Gohlsch, Schneider and Kaltenbach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Active zones of axo-somatic terminals on fusiform cells. (A,B) Examples of terminals (T) containing multiple active zones (small black arrow-heads). White arrows point to mitochondria. (C,D) Higher magnification views of synaptic junctions containing active zones (cluster of vesicles between black arrowheads pointing towards each other). Note the absence of PSDs beneath the postsynaptic membrane (yellow arrows), indicating that these were symmetric synapses. The vesicles of the active zone appear amidst a larger (reserve) pool of vesicles that fill the rest of the terminal (long black arrows in A).