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. 2014 Sep 23;8:325. doi: 10.3389/fnbeh.2014.00325

Figure 1.

Figure 1

Decreased anxiety-like behaviors and unchanged depression-like behaviors in the central 5-HT-deficient mice. (A, B) Pet1-expressing cells still exist in the dorsal raphe nucleus of PC/Tph2 mice. Scale bar: 300 μm. (C) There are no differences between PC/Tph2 mice and controls in the total distance traveled in the open field test during a 30-min period. (D, E) In the light/dark box test, PC/Tph2 mice spend more time in the light box (D, p < 0.01), and enter more times into the light box compared with the control mice (E, p < 0.01). (F, G) In the elevated plus maze test, longer time in the open arms is spent by PC/Tph2 mice (F,p < 0.001), and they also enter more times into the open arms compared with controls (G, p < 0.01). (H) Immobility time in the forced swimming test shows no differences between PC/Tph2 mice and control mice. (I) Immobility time in the tail suspension test is not different between PC/Tph2 mice and control mice. (J) Immobility time in the forced swimming test shows no differences between PC/Lmx1b mice and control mice. (K) Immobility time in the tail suspension test shows no differences between PC/Lmx1b mice and control mice. “n” denotes the animal number in figures. CTL: control. All data are expressed as mean ± SEM. ** and *** indicate p < 0.01 and p < 0.001.